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TRPV4 activation by thermal and mechanical stimuli in disease progression.
Laboratory Investigation ( IF 5 ) Pub Date : 2020-01-02 , DOI: 10.1038/s41374-019-0362-2
Koji Shibasaki 1
Affiliation  

Body temperature is an important determinant in regulating the activities of animals. In humans, a mild 0.5 °C hyperthermia can cause headaches, demonstrating that the maintenance of normal body temperature is a key for our health. In a more extreme example, accidental acute hypothermia can lead to severe shivering, loss of consciousness, or death, although the details of these mechanisms are poorly understood. We previously found that the TRPV4 ion channel is constitutively activated by normal body temperature. The activation threshold of TRPV4 is >34 °C in the brain, which enables TRPV4 to convert thermal information into cellular signaling. Here we review the data which describe how the deletion of TRPV4 evokes abnormal behavior in mice. These studies demonstrate that the maintenance of body temperature and the sensory system for detecting body temperature, such as via TRPV4, are critical components for normal cellular function. Moreover, abnormal TRPV4 activation exacerbates cell death, epilepsy, stroke, brain edema, or cardiac fibroblast activity. In this review, we also summarize the findings related to TRPV4 and disease.

中文翻译:

TRPV4 在疾病进展中通过热和机械刺激激活。

体温是调节动物活动的重要决定因素。在人类中,0.5 °C 的轻度高温会引起头痛,这表明维持正常体温是我们健康的关键。在一个更极端的例子中,意外的急性体温过低会导致严重的颤抖、意识丧失或死亡,尽管人们对这些机制的细节知之甚少。我们之前发现 TRPV4 离子通道由正常体温组成型激活。TRPV4 的激活阈值在大脑中 >34 °C,这使得 TRPV4 能够将热信息转换为细胞信号。在这里,我们回顾了描述 TRPV4 缺失如何引起小鼠异常行为的数据。这些研究表明,维持体温和检测体温的感觉系统(例如通过 TRPV4)是正常细胞功能的关键组成部分。此外,异常的 TRPV4 激活会加剧细胞死亡、癫痫、中风、脑水肿或心脏成纤维细胞活性。在这篇综述中,我们还总结了与 TRPV4 和疾病相关的发现。
更新日期:2020-01-04
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