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Human CSF monoclonal LGI1 autoantibodies increase neuronal excitability
Annals of Neurology ( IF 11.2 ) Pub Date : 2020-01-27 , DOI: 10.1002/ana.25666
Hans-Christian Kornau 1, 2 , Jakob Kreye 1, 3, 4 , Alexander Stumpf 2 , Yuko Fukata 5, 6 , Daniel Parthier 2 , Rosanna P Sammons 2 , Barbara Imbrosci 2 , Sarah Kurpjuweit 1, 3 , Alexander B Kowski 3 , Masaki Fukata 5, 6 , Harald Prüss 1, 3 , Dietmar Schmitz 1, 2, 7
Affiliation  

Leucine‐rich glioma‐inactivated 1 (LGI1) encephalitis is the second most common antibody‐mediated encephalopathy, but insight into the intrathecal B‐cell autoimmune response, including clonal relationships, isotype distribution, frequency, and pathogenic effects of single LGI1 antibodies, has remained limited.

中文翻译:

人脑脊液单克隆 LGI1 自身抗体增加神经元兴奋性

富含亮氨酸的胶质瘤灭活 1 (LGI1) 脑炎是第二种最常见的抗体介导的脑病,但深入了解鞘内 B 细胞自身免疫反应,包括克隆关系、同种型分布、频率和单个 LGI1 抗体的致病作用,仍然有限。
更新日期:2020-01-27
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