Periodontitis is a potential source of permanent systemic inflammation that initiates renal dysfunction and contributes to the development of chronic kidney diseases (CKDs). Although numerous studies have confirmed the bidirectional role of periodontal infection and renal inflammation, no literature has yet highlighted the sophisticated pathogenic mechanisms by which periodontal pathogens, particularly Porphynomonas Gingivalis, induce renal dysfunction and contributed in the development of CKDs. The present review aims to critically analyze and highlight the novel pathogenesis of periodontitis induced CKDs.

中文翻译：

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牙周病原体对肾功能不全的可能致病机制的最新进展

牙周炎是永久性全身性炎症的潜在来源，可引发肾功能不全并促进慢性肾脏疾病（CKD）的发展。尽管大量研究证实了牙周感染和肾脏炎症的双向作用，但尚无文献强调牙周病原体（特别是牙龈卟啉单胞菌）诱发肾功能不全并促成CKD发生的复杂的致病机制。本文旨在对牙周炎引起的CKDs的新发病机制进行严格的分析和重点研究。