Increasing levels of resistance to antimicrobial agents have created chaos in the health sector, with several infections not responding to antibiotic treatments. Search for alternative strategies has looked at bacteriophages as potential therapeutics and in the last couple of years. There are reports of phages being successfully used to treat life-threatening infections. Phages are also mobile elements that exchange genes between and within different bacterial species and account significantly for strain differences across and within a species. A gap in metagenomics analysis and conservative methods of detection have failed to give an accurate account of the role of bacteriophages in antimicrobial resistance. Recent studies have focussed on the role of bacteriophages in the adaptation of pathogens to new hosts and the emergence of multidrug-resistance, which are a significant concern against phage therapy. This article presents a comprehensive account of weighing the odds of phage therapy verses phage-mediated antimicrobial resistance.

对抗菌剂的抗药性水平的提高在卫生部门造成混乱，一些感染对抗生素治疗无反应。在寻找替代策略的过程中，近几年来噬菌体已成为潜在的治疗方法。有报道称噬菌体已成功用于治疗威胁生命的感染。噬菌体还是可移动的元件，可在不同细菌物种之间和内部交换基因，并显着说明物种之间和内部的菌株差异。宏基因组学分析和保守的检测方法之间的差距未能准确说明噬菌体在抗菌素耐药性中的作用。最近的研究集中在噬菌体在使病原体适应新宿主和多重耐药性出现方面的作用，这是对噬菌体治疗的重要关注。本文介绍了权衡噬菌体治疗与噬菌体介导的抗菌素耐药性的几率的综合说明。