Endometriosis is one of the most frequent gynecological disorders defined as the existence and growth of endometrial tissue outside the uterine cavity. Aim of this study was to evaluate the level of six oxidative stress markers in the serum of patients with and without endometriosis. This study included 46 women who were undergoing laparoscopy. The participants were divided into two groups based on their laparoscopic results. Thirty-one women had visually and histopathologically confirmed endometriosis, whereas 15 did not. The serum level of ADMA (asymmetric dimethylarginine), MCP1 (monocyte chemoattractant protein 1), MMP2 (matrix metalloproteinases 2), MMP9 (matrix metalloproteinases 9), RANTES (regulated upon activation, normal T cell expressed and presumably secreted), and VEGF-A (vascular endothelial growth factor) as oxidative stress markers were measured and compared between the two groups. No significant difference in the ADMA, MCP1, MMP2, MMP9, RANTES, and VEGF-A serum levels was detected between the entometriosis patients and controls. The disease stage did not affect any of the markers’ level either. Women with endometriosis had menarche at an earlier age compared to controls [11.7 (SD 1.09) vs 12.6 (SD 1.4), p = 0.04)]. These results suggest that there is no association between endometriosis and increased oxidative stress. The elevation and possible role of oxidative stress markers in the diagnosis and pathogenesis of endometriosis should be evaluated in more extended studies.

中文翻译：

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子宫内膜异位症女性的初潮年龄和氧化应激指标

子宫内膜异位症是最常见的妇科疾病之一，定义为子宫腔外子宫内膜组织的存在和生长。这项研究的目的是评估子宫内膜异位症患者和非子宫内膜异位患者血清中六个氧化应激标志物的水平。这项研究包括了46位接受腹腔镜检查的女性。根据他们的腹腔镜检查结果将参与者分为两组。31名妇女在视觉和组织病理学上证实了子宫内膜异位，而15名没有。血清ADMA（不对称二甲基精氨酸），MCP1（单核细胞趋化蛋白1），MMP2（基质金属蛋白酶2），MMP9（基质金属蛋白酶9），RANTES（激活后调节，正常T细胞表达并推测分泌）的血清水平，两组之间的氧化应激标志物和VEGF-A（血管内皮生长因子）进行了比较。子宫内膜异位症患者和对照组之间的ADMA，MCP1，MMP2，MMP9，RANTES和VEGF-A血清水平无显着差异。疾病阶段也不影响任何标志物的水平。与对照组相比，子宫内膜异位症的女性初潮年龄更早[11.7（SD 1.09）对12.6（SD 1.4），p  = 0.04）]。这些结果表明子宫内膜异位症和增加的氧化应激之间没有关联。氧化应激标志物在子宫内膜异位症的诊断和发病机制中的升高及其可能的作用应在更广泛的研究中进行评估。