We describe a case of cryptococcal meningitis diagnosed in an immunocompetent patient, with no apparent predisposing conditions, living in Northern Italy. The patient was initially admitted for visual disturbs with nausea and cervical pain, but magnetic resonance imaging of the brain showed a diencephalic lesion. Colonies of Cryptococcus gattii species complex were isolated from cerebrospinal fluid. Antifungal therapy was started and conditions of the patient improved in 2 months. The fungal isolate was identified as C. gattii molecular type VGI, mating type αB, and genotype ST156. This is the most common C. gattii species complex genotype circulating in Europe and in Italy suggesting that the infection was probably acquired in Italy since the patient did not report any recent travel abroad.

中文翻译：

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在意大利北部，第一个因感染隐球菌VGI导致免疫功能正常的宿主中的隐球菌脑膜炎病例

我们描述了一个居住在意大利北部，没有明显诱因的有免疫能力的患者中诊断出的隐球菌性脑膜炎病例。该患者最初因恶心和宫颈疼痛而出现视力障碍，但大脑的磁共振成像显示有脑性病变。从脑脊髓液中分离出加氏隐球菌种复合体的菌落。开始抗真菌治疗，患者状况在2个月内得到改善。真菌分离物被鉴定为加迪梭菌分子类型VGI，交配类型αB和基因型ST156。这是最常见的加迪 在欧洲和意大利流行的多种复杂基因型表明该感染可能是在意大利获得的，因为该患者没有报告最近出国旅行。