Abstract

Purpose

Heterotopic ossification (HO) is the abnormal osteogenesis in non-skeletal tissue. It can be difficult to detect, as it can mimic other conditions clinically and on imaging studies. The purpose of this study was to find the added value of SPECT-CT in accurate detection of HO.

Materials and methods

A total of 1780 reports on the PACS system of patients underwent bone scintigraphy at the Department of Nuclear Medicine and were filtered for the term “HO” or “heterotopic bone formation” and “SPECT-CT”. Thirty-four patients fulfilled this criterion. All patients had bone scintigraphy and SPECT/CT in the same occasion. Images were reviewed by two nuclear medicine physicians blindly. The certainty of the presence of extra-skeletal soft tissue ossification on the planar with SPECT was graded as “definitely present”, “maybe present”, or “not present”, and the same was determined on planar with SPECT-CT images.

Results

Based on SPECT/CT, 23 (67.6%) patients were found to have HO, and 11 (32.4%) did not have confirming findings. Of the 23 positive patients on SPECT/CT, eight (34.8%) showed “definitely present” and 12 (52.2%) patients were under “maybe present” on SPECT only. Three (13%) patients were negative on the SPECT and showed evidence of HO on CT. Of the 11 patients that did not demonstrate definite evidence of HO on SPECT/CT, seven (63.6%) were negative on SPECT alone and, four (36.4%) were under “maybe present” on SPECT. The definite detection of HO was statistically significant higher when CT is added to SPECT.

Conclusions

Our findings suggest that adding the CT component to SPECT is valuable in the detection of HO.

中文翻译：

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SPECT-CT在骨闪烁显像术中检测异位骨化的附加价值

摘要

目的

异位骨化（HO）是非骨骼组织中异常的成骨作用。由于它可以模仿临床和影像学研究中的其他情况，因此可能很难检测到。这项研究的目的是发现SPECT-CT在准确检测HO中的附加价值。

材料和方法

共有1780篇关于患者的PACS系统的报告在核医学部进行了骨闪烁显像，并被过滤掉以表示“ HO”或“异位骨形成”和“ SPECT-CT”。三十四名患者满足了该标准。所有患者在同一情况下均接受了骨闪烁显像和SPECT / CT检查。图像由两名核医学医师盲目审查。用SPECT在平面上存在骨骼外软组织骨化的确定性被评定为“绝对存在”，“可能存在”或“不存在”，并在具有SPECT-CT图像的平面上确定了相同程度。

结果

根据SPECT / CT，发现23例（67.6％）患有HO，11例（32.4％）没有确诊。在SPECT / CT的23例阳性患者中，只有8例（34.8％）表现为“肯定存在”，而12例（52.2％）的患者仅在SPECT之下处于“可能存在”状态。3例（13％）患者SPECT阴性，CT上显示HO证据。在11位未在SPECT / CT上显示出明确HO证据的患者中，有7位（63.6％）仅在SPECT上阴性，而4位（36.4％）在SPECT上处于“可能存在”状态。将CT添加到SPECT中时，HO的确定检测在统计学上较高。

结论

我们的发现表明，将CT成分添加到SPECT对检测HO很有用。