Abstract

Mini abstract

This is a systematic review aiming to evaluate the recovery of bone mass after lactation-related loss. Bone loss is transitory with recovery depending on the return of menstruation and weaning, and several compensatory homeostatic mechanisms are involved to minimize any significant damage to the maternal skeleton.

Abstract

Lactation has been associated with significant temporary bone loss, especially during the exclusive breastfeeding period. In the bone recovery phase, there is wide methodological heterogeneity among clinical trials, including follow-up timing, methods and sites of bone measurements, and body composition changes. The purpose of this study is to perform a systematic review and meta-analysis aiming to evaluate the recovery rate of bone mass after lactation-related loss, including the PubMed, Web of Science, and Scopus databases, with no publication date restrictions. The following MeSH terms were used: “bone diseases,” “bone resorption,” “bone density,” “osteoporosis,” “calcium,” “postpartum period,” “weaning,” “breast feeding,” and “lactation.” The inclusion criteria were as follows: prospective human studies in women of reproductive age and bone measurements with two assessments in the postpartum period at least: the first one within the first weeks of lactation and another one 12 months after delivery, 3 months following the return of menses or 3 months postweaning. This research was recorded on the Prospero database (CRD42018096586Bone). A total of 9455 studies were found and 32 papers met the inclusion criteria. The follow-up period ranged from one to 3.6 years postpartum. Lactation was associated with transient bone loss, with a strong tendency to recover in all the sites studied, depending on the return of menstruation and weaning. Small deficits in the microarchitecture of the peripheral skeleton may be present, especially in women with prolonged breastfeeding, but with no deficit regarding the hip geometry was found. Women with a successive gestation after prolonged lactation and women who had breastfed when adolescents had no significant bone loss. Bone loss related to lactation is transitory, and several compensatory homeostatic mechanisms are involved to minimize any significant damage to the maternal skeleton.

中文翻译：

---

哺乳后女性的骨骼健康如何恢复？系统评价和荟萃分析

摘要

迷你文摘

这是一项系统评价，旨在评估与泌乳有关的损失后骨量的恢复。骨丢失是短暂的，随着月经和断奶的恢复而恢复，并且涉及一些补偿性体内平衡机制，以最大程度地减少对孕产妇骨骼的任何重大损害。

抽象

哺乳期与暂时性的严重骨质流失有关，尤其是在纯母乳喂养期间。在骨骼恢复阶段，临床试验之间存在广泛的方法异质性，包括随访时间，骨骼测量的方法和部位以及身体成分的变化。这项研究的目的是进行系统的综述和荟萃分析，旨在评估与泌乳相关的损失后的骨量恢复率，包括PubMed，Web of Science和Scopus数据库，无发布日期限制。使用了以下MeSH术语：“骨骼疾病”，“骨骼吸收”，“骨骼密度”，“骨质疏松症”，“钙”，“产后时期”，“断奶”，“母乳喂养”和“哺乳期”。纳入标准如下：对育龄妇女和骨骼测量进行的前瞻性人体研究至少在产后进行了两次评估：第一次是在哺乳期的最初几周内进行的，另一次是在分娩后12个月，经血恢复后3个月或断奶后3个月。这项研究记录在Prospero数据库（CRD42018096586Bone）上。共发现9455项研究，有32篇论文符合纳入标准。随访期从产后1年到3。6年不等。泌乳与短暂的骨质流失有关，在所有研究的部位都有强烈的恢复趋势，这取决于月经和断奶的恢复。外周骨骼的微结构可能存在少量缺陷，特别是在母乳喂养时间较长的女性中，但未发现髋关节几何结构缺陷。长时间哺乳后连续怀孕的妇女和青春期没有明显骨质流失的母乳喂养的妇女。与泌乳有关的骨质流失是暂时的，并且涉及多种补偿性体内平衡机制，以最大程度地减少对母体骨骼的任何重大损害。