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Probiotic treatment induced change of inflammation related metabolites in IBS-D patients/double-blind, randomized, placebo-controlled trial.
Food Science and Biotechnology ( IF 2.9 ) Pub Date : 2019-12-23 , DOI: 10.1007/s10068-019-00717-2
Jinjoo Kim 1, 2 , Kumsun Cho 3 , Joo Sung Kim 1 , Hyun Chae Jung 1 , Bumsik Kim 4 , Myeong Soo Park 5 , Geun Eog Ji 5 , Joo-Youn Cho 3, 6 , Kyoung Sup Hong 7
Affiliation  

There have been many studies suggesting that probiotics are effective in patients with diarrhea-predominant irritable bowel syndrome (IBS-D). However, its mechanism of action as well as prediction of response is still to be elucidated. In the present study, to find out metabolomic characteristics of probiotic effect in IBS-D, we compared IBS symptom changes and metabolomic characteristics in the subjects’ urine samples between multi-strain probiotics (one strain of Lactobacillus sp. and four strains of Bifidobacterium sp.) group (n = 32) and placebo group (n = 31). After 8 weeks’ administration (3 times/day), dissatisfaction in bowel habits and stool frequencies were significantly improved. Also, probiotics group had significantly changed seven metabolites including palmitic acid methyl ester (PAME) and 4,6-dihydroxyquinoline, 4-(2-aminophenyl)-2,4-dioxobutanoic acid (DOBA). According to IBS-SSS and IBS-QoL questionnaires, IBS-SSS responders showed higher PAME levels and IBS-QoL responders showed lower DOBA levels. This suggests potential role of these metabolites as a biomarker to predict probiotics effect in IBS-D patients.



中文翻译:

益生菌治疗在IBS-D患者/双盲,随机,安慰剂对照试验中诱发炎症相关代谢产物的变化。

有许多研究表明,益生菌对腹泻型肠易激综合症(IBS-D)患者有效。但是,其作用机理以及对反应的预测仍待阐明。在本研究中,为了找出IBS-D中益生菌作用的代谢组学特征,我们比较了多菌株益生菌(一种乳酸杆菌属菌株和四种双歧杆菌菌株)受试者尿液样品中IBS症状的变化和代谢组学特征。sp。)组(n = 32)和安慰剂组(n = 31)。给药8周(每天3次)后,排便习惯和粪便频率的不满意得到明显改善。益生菌组还显着改变了7种代谢产物,包括棕榈酸甲酯(PAME)和4,6-二羟基喹啉,4-(2-氨基苯基)-2,4-二氧代丁酸(DOBA)。根据IBS-SSS和IBS-QoL调查问卷,IBS-SSS响应者显示较高的PAME水平,IBS-QoL响应者显示较低的DOBA水平。这表明这些代谢物作为预测IBS-D患者益生菌作用的生物标志物的潜在作用。

更新日期:2019-12-23
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