Waste management is a major part of the food industry. The present study was designed to utilize the discarded byproduct of Schisandra chinensis Baillon. The antioxidant and anti-inflammatory effects of a 30% ethanol fraction (RPG-OM-30E) from the fermented hot water extraction of the Schisandra chinensis Baillon byproduct were investigated using RAW 264.7 cells and zebrafish larvae. RPG-OM-30E reduced lipopolysaccharide (LPS)-induced nitric oxide production in the RAW 264.7 cells. Additionally, RPG-OM-30E inhibited mRNA expression and protein secretion of pro-inflammatory cytokines, such as interleukin-6 (Il-6) and interleukin-1β (Il-1β). The anti-inflammatory effects of RPG-OM-30E were tested in Tg(mpx::EGFP)ⁱ¹¹⁴ zebrafish larvae. Neutrophil migration to a wound site was decreased by RPG-OM-30E. Neutrophil aggregation was also inhibited by RPG-OM-30E after induction of an LPS-induced immune response in the yolk. Finally, the antioxidant and hepatoprotective effects of RPG-OM-30E were examined in vivo. Mice with induced oxidative damage recovered from the stress following RPG-OM-30E treatment.

废物管理是食品工业的重要组成部分。本研究旨在利用五味子的五味子废弃副产物。使用RAW 264.7细胞和斑马鱼幼虫研究了五味子五味子副产物发酵热水提取物中30％乙醇馏分（RPG-OM-30E）的抗氧化和抗炎作用。RPG-OM-30E减少了RAW 264.7细胞中脂多糖（LPS）诱导的一氧化氮生成。此外，RPG-OM-30E抑制促炎细胞因子，如白细胞介素-6（mRNA表达和蛋白质分泌伊尔- 6）和白介素1β（伊尔- 1β）。在Tg（mpx :: EGFP）ⁱ¹¹⁴斑马鱼幼虫中测试了RPG-OM-30E的抗炎作用。RPG-OM-30E减少了中性粒细胞向伤口部位的迁移。在卵黄中诱导LPS诱导的免疫反应后，RPG-OM-30E也抑制了中性粒细胞的聚集。最后，在体内检查了RPG-OM-30E的抗氧化和保肝作用。RPG-OM-30E处理后，具有氧化应激的小鼠从压力中恢复。