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A fall in the previous 12 months predicts fracture in the subsequent 5 years in postmenopausal women.
Breast Cancer Research and Treatment ( IF 3.8 ) Pub Date : 2019-12-19 , DOI: 10.1007/s00198-019-05255-5
N Afrin 1 , R Sund 1 , R Honkanen 1, 2 , H Koivumaa-Honkanen 1, 2, 3, 4, 5, 6, 7 , T Rikkonen 1 , L Williams 8 , H Kröger 1, 9
Affiliation  

PURPOSE The purpose of this study was to evaluate if a history of falls predicts future postmenopausal fractures and if this prediction variesaccording to frequency, mechanism, and severity of falls and site of fractures. METHODS This study used data from OSTPRE prospective cohort. Total study population consisted of 8744 postmenopausal women (mean age 62.2 years) who responded to postal enquiry in 1999 (baseline) and in 2004 (follow-up). RESULTS Women were classified by frequency (non/occasional/frequent fallers), mechanism (slip/nonslip), and severity (injurious/ non-injurious) of falls and fractures by site (major osteoporotic/other). A total of 1693 (19.4%) women reported a fall during the preceding 12 months in 1999; 812 a slip fall, 654 a nonslip, 379 an injurious fall, and 1308 a non-injurious fall. A total of 811 women (9.3%) sustained a fracture during the 5-year follow-up period (1999-2004); 431 major osteoporotic fractures and 380 other fractures. Compared with non-fallers, earlier falls predicted subsequent fractures with an OR of 1.41 (95% CI 1.19-1.67, p ≤ 0.001), 1.43 (95% CI 1.14-1.80, p = 0.002) for earlier slip falls, and 1.35 (95% CI 1.04-1.74, p = 0.02) for earlier nonslip falls. Earlier injurious falls predicted future fractures (OR = 1.64, 95% CI 1.21-2.23, p ≤ 0.01), especially other fractures (OR = 1.86, 95% CI 1.24-2.80, p ≤ 0.01), but not major osteoporotic fractures (OR = 1.37, 95% CI 0.89-2.10, p = 0.151). Fracture risk predictions for earlier non-injurious falls was OR = 1.36, 95% CI 1.12-1.64, p = 0.002. These risk patterns remain same after adjustments. CONCLUSION History of falls (especially injurious falls) predicts subsequent fractures (mainly other fractures compared with major osteoporotic fractures) inpostmenopausal women. We aimed to investigate if history of falls (frequency, mechanism, and severity) is a predictor of future fractures in postmenopausal women. Our results indicate that history of falls (especially injurious falls) appeared to be an indicator for subsequent fracture overall. Earlier injurious falls were stronger predictors for future other fractures than for typical major osteoporotic fractures.

中文翻译:

前12个月的下降预示了绝经后妇女随后5年的骨折。

目的本研究的目的是评估跌倒的历史是否预示了绝经后的未来骨折以及该预测是否根据跌倒的频率,机制,严重性和骨折部位而变化。方法本研究使用了OSTPRE前瞻性队列的数据。研究的总人口包括8744名绝经后妇女(平均年龄62.2岁),她们在1999年(基线)和2004年(随访)对邮政询问做出了回应。结果按部位(主要/严重的骨质疏松/其他)跌倒和骨折的发生频率(非/偶然/频繁跌倒),机制(滑倒/防滑)和严重程度(伤害/非伤害)对妇女进行分类。在1999年的前12个月中,共有1693名(19.4%)妇女报告了跌倒;812滑倒,654滑倒,379滑倒,1308滑倒。共有811名女性(9。3%)在5年的随访期内(1999-2004年)骨折。431例主要骨质疏松性骨折和380例其他骨折。与非跌倒者相比,早期跌倒预测的后续骨折OR为1.41(95%CI 1.19-1.67,p≤0.001),1.43(95%CI 1.14-1.80,p = 0.002)对于早期滑倒和1.35( 95%CI 1.04-1.74,p = 0.02)。较早的伤害性跌倒预示着未来的骨折(OR = 1.64,95%CI 1.21-2.23,p≤0.01),尤其是其他骨折(OR = 1.86,95%CI 1.24-2.80,p≤0.01),但不是主要的骨质疏松性骨折(OR = 1.37,95%CI 0.89-2.10,p = 0.151)。早期非伤害性跌倒的骨折风险预测为OR = 1.36,95%CI 1.12-1.64,p = 0.002。调整后,这些风险模式保持不变。结论跌倒的历史(尤其是伤害性跌倒)可预测绝经后妇女的后续骨折(主要是与主要骨质疏松性骨折相比的其他骨折)。我们旨在调查跌倒的历史(频率,机制和严重程度)是否可预测绝经后女性未来的骨折。我们的结果表明跌倒的历史(尤其是伤害性跌倒)似乎是随后整体骨折的指标。较其他典型的主要骨质疏松性骨折,较早的伤害性跌倒更能预测未来其他骨折。我们的结果表明跌倒的历史(尤其是伤害性跌倒)似乎是随后整体骨折的指标。较其他典型的主要骨质疏松性骨折,较早的伤害性跌倒更能预测未来其他骨折。我们的结果表明跌倒的历史(尤其是伤害性跌倒)似乎是随后整体骨折的指标。较其他典型的主要骨质疏松性骨折,较早的伤害性跌倒更能预测未来其他骨折。
更新日期:2020-04-20
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