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Scenario analysis on the use of rodenticides and sex-biasing gene drives for the removal of invasive house mice on islands
Biological Invasions ( IF 2.9 ) Pub Date : 2020-01-02 , DOI: 10.1007/s10530-019-02192-6
Megan E. Serr , Rene X. Valdez , Kathleen S. Barnhill-Dilling , John Godwin , Todd Kuiken , Matthew Booker

Abstract

Since the 1960s conservation efforts have focused on recovering island biodiversity by eradicating invasive rodents. These eradication campaigns have led to considerable conservation gains, particularly for nesting seabirds. However, eradications are complex and lengthy endeavors and are even more challenging when humans are co-inhabitants of the targeted island. Furthermore, the method of eradication matters and recent proposals to consider genetic technologies for rodent eradication require specific scrutiny. One such technology is the potential use of a gene drive for biasing offspring sex ratios in invasive house mice, Mus musculus, that would spread and prevent the production of one sex, allowing die-off from lack of reproduction and natural attrition. Practitioners can gain insight into the potential for adoption of this technology from examining stakeholder engagement. This paper uses scenario analysis to address the eradication of rodents on inhabited and uninhabited islands, by specifically comparing the traditional approach of using rodenticides with sex-biasing gene drives. Concurrently the International Union for Conservation of Nature is assessing the risks and value of gene drives in general for conservation. Hence, we make the case that the ethical challenges with the use of gene drive sex-biasing techniques and the effectiveness of this tool will rely as much on its public acceptance and its democratic use as the actual science used to construct the technology.



中文翻译:

关于使用灭鼠剂和性别偏见基因驱动器去除岛上侵入性家鼠的方案分析

摘要

自1960年代以来,保护工作一直致力于通过消灭入侵性啮齿动物来恢复岛屿生物多样性。这些根除运动已取得了可观的保护成果,特别是在筑巢海鸟方面。然而,根除工作是复杂而漫长的,当人类是目标岛屿的同居者时,根除甚至更具挑战性。此外,根除的方法很重要,并且最近考虑将遗传技术用于啮齿动物的根除的建议也需要进行详细审查。一种这样的技术是潜在地使用基因驱动来改变侵入性家鼠小家鼠的后代性别比例。会传播并阻止一种性行为的产生,从而因缺乏繁殖和自然损耗而死亡。通过检查利益相关者的参与,从业者可以洞悉采用该技术的潜力。本文通过情景分析来解决在无人岛和无人岛上的灭鼠问题,方法是将使用杀鼠剂和偏见性基因驱动的传统方法进行专门比较。同时,国际自然保护联盟正在评估总体上基因保护的风险和价值。因此,我们认为,使用基因驱动性别偏向技术的伦理挑战以及该工具的有效性将与构建该技术的实际科学一样,在很大程度上取决于其公众认可度和民主使用程度。

更新日期:2020-01-04
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