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Stress responses linked to antimicrobial resistance in Acinetobacter species.
Applied Microbiology and Biotechnology ( IF 5 ) Pub Date : 2020-01-03 , DOI: 10.1007/s00253-019-10317-z
Bora Shin 1 , Chulwoo Park 1 , Woojun Park 1
Affiliation  

Since the last 20 years, bacteria of the genus Acinetobacter have been the leading cause of hospital-acquired infections. In addition to the ability of Acinetobacter species to acquire rapid antibiotic resistance, limited knowledge on the mechanisms of multidrug resistance to antibiotics limits the treatment options for such infections. Here, we present a review of cellular processes, including oxidative stress defense, energy metabolism, ppGpp signaling, toxin-antitoxin system, and quorum sensing network in Acinetobacter species and their roles in antimicrobial resistance. Although inhibition of stress responses is an attractive approach to the development of effective antimicrobial therapeutic agents, it is crucial to understand the mechanisms that cause antibiotic resistance in Acinetobacter species, as they are not as well studied as those in other pathogenic bacteria. RelA/SpoT has been shown to be involved in ppGpp synthesis in all 50 genomes of 35 Acinetobacter species. However, toxin-antitoxin (TA) systems are present in less than 30% of the 50 genomes (28/30% of SplT/A; 14/14% of HigB/A; 4/6% of HicA/B), except the RelE/B system (30/78%). These data suggested that ppGpp signaling is conserved in Acinetobacter species, but TA systems are not. This review describes our current knowledge on stress responses with respect to antibiotic resistance or tolerance in pathogenic and non-pathogenic Acinetobacter species.

中文翻译:

不动杆菌属中与抗药性有关的应激反应。

自最近20年以来,不动杆菌属细菌一直是医院获得性感染的主要原因。除不动杆菌具有快速获得抗生素抗药性的能力外,对抗生素的多药抗药性机制的有限知识也限制了此类感染的治疗选择。在这里,我们介绍细胞过程,包括氧化应激防御,能量代谢,ppGpp信号,毒素-抗毒素系统和不动杆菌属群体感应网络及其在抗菌素耐药性中的作用的综述。尽管抑制压力反应是开发有效的抗菌治疗剂的一种有吸引力的方法,但了解引起不动杆菌属细菌耐药性的机制至关重要,因为对它们的研究还不如对其他致病细菌的研究。RelA / SpoT已显示参与35种不动杆菌属的所有50个基因组中的ppGpp合成。但是,毒素-抗毒素(TA)系统存在于50个基因组中的不到30%(SplT / A为28/30%; HigB / A为14/14%; HicA / B为4/6%)。 RelE / B系统(30/78%)。这些数据表明ppGpp信号在不动杆菌属中是保守的,但TA系统不是。这篇评论描述了我们目前对致病性和非致病性不动杆菌属中抗生素抗性或耐受性的应激反应的认识。除RelE之外,毒素-抗毒素(TA)系统存在于50个基因组中的不足30%(SplT / A为28/30%; HigB / A为14/14%; HicA / B为4/6%)。 / B系统(30/78%)。这些数据表明ppGpp信号在不动杆菌属中是保守的,但TA系统不是。这篇评论描述了我们目前对致病性和非致病性不动杆菌属中抗生素抗性或耐受性的应激反应的认识。除RelE之外,毒素-抗毒素(TA)系统存在于50个基因组中的不足30%(SplT / A为28/30%; HigB / A为14/14%; HicA / B为4/6%)。 / B系统(30/78%)。这些数据表明ppGpp信号在不动杆菌属中是保守的,但TA系统不是。这篇评论描述了我们目前对致病性和非致病性不动杆菌属中抗生素抗性或耐受性的应激反应的认识。
更新日期:2020-01-04
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