Although burst and high-frequency (HF) spinal cord stimulation (SCS) relieve neuropathic pain, their effects on neuronal hyperexcitability have not been compared. Specifically, it is unknown how the recharge components of burst SCS—either actively balanced or allowed to passively return—and/or different frequencies of HF SCS compare in altering neuronal activity. Neuronal firing rates were measured in the spinal dorsal horn on day 7 after painful cervical nerve root compression in the rat. Motor thresholds (MTs) and evoked neuronal recordings were collected during noxious stimuli before (baseline) and after delivery of SCS using different SCS modes: 10 kHz HF, 1.2 kHz HF, burst with active recharge, or burst with passive recharge. Spontaneous firing rates were also evaluated at baseline and after SCS. The average MT for 10 kHz SCS was significantly higher (p < 0.033) than any other mode. Burst with passive recharge was the only SCS mode to significantly reduce evoked (p = 0.019) and spontaneous (p = 0.0076) firing rates after noxious pinch. This study demonstrates that HF and burst SCS have different MTs and effects on both evoked and spontaneous firing rates, indicating they have different mechanisms of providing pain relief. Since burst with passive recharge was the only waveform to reduce firing, that waveform may be important in the neurophysiological response to stimulation.

中文翻译：

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突发性和高频脊髓刺激对神经根病后脊髓神经元活动的影响不同

尽管爆发和高频（HF）脊髓刺激（SCS）缓解了神经性疼痛，但尚未比较它们对神经元过度兴奋性的影响。具体而言，尚不清楚突发SCS的补给成分（主动平衡或允许被动返回）和/或HF SCS的不同频率在改变神经元活动方面如何进行比较。在大鼠颈椎神经根受压后第7天测量脊髓背角的神经元放电速率。运动阈值（MTs）和诱发的神经元记录是在SCS传递之前（基线）和之后使用不同的SCS模式（10 kHz HF，1.2 kHz HF，主动充电猝发或被动充电猝发）进行有害刺激期间收集的。在基线和SCS之后也评估自发放电率。p  <0.033）。被动补给爆发是唯一的SCS模式，可以显着降低 有毒捏紧后的诱发（p  = 0.019）和自发（p = 0.0076）发射率。这项研究表明，HF和爆发性SCS具有不同的MT值以及对诱发和自发放电率的影响，表明它们具有减轻疼痛的机制。由于带有被动充电的猝发是减少放电的唯一波形，因此该波形在刺激神经生理反应中可能很重要。