PURPOSE To evaluate pancreatic T1 mapping and extracellular volume (ECV) fraction's feasibility to assess impaired glucose tolerance (IGT) patients. METHODS A total of 45 consecutive patients with known or suspected pancreatic disease underwent contrast-enhanced magnetic resonance (MR) imaging, including T1 mapping, using saturation recovery sequence. Patients were classified into three groups based on the American Diabetes Association criteria: no-diabetes subjects, HbA1c < 5.7%; pre-diabetes, 5.7% ≤ HbA1c < 6.5%; and type 2 diabetes mellitus (T2DM), HbA1c ≥ 6.5%. Pre-contrast pancreatic T1 value and ECV of the pancreas were computed, and then pre-contrast pancreatic T1 value, ECV and HbA1c values were compared. The present prospective study was approved by our institutional review board. Written informed consent was obtained from all patients. RESULTS A positive correlation between HbA1c values and both pre-contrast pancreatic T1 value and ECV (r = 0.79, P < 0.001 and r = 0.60, P < 0.001, respectively) were observed. The pre-contrast pancreatic T1 value and ECV were significantly higher in T2DM vs. no-diabetes subjects and pre-diabetes (P < 0.001). No significant difference between two qualitative values (P = 0.14) was found, however, the sensitivity, specificity, and area under the receiver-operating-characteristic curve differentiating no-diabetes subjects and pre-diabetes from T2DM were superior in ECV (100%, 93.5%, and 0.990) vs. pre-contrast pancreatic T1 values (84.6%, 96.8%, and 0.906). CONCLUSIONS The ECV of the pancreas could serve as a potential imaging biomarker for the assessment of pancreatic fibrosis leading to IGT.

中文翻译：

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葡萄糖耐受不良患者使用T1作图的胰腺细胞外体积分数。

目的评估胰腺T1作图和细胞外体积（ECV）分数评估糖耐量减低（IGT）患者的可行性。方法总共45例连续的已知或疑似胰腺疾病患者接受了饱和度恢复序列的对比增强磁共振（MR）成像，包括T1作图。根据美国糖尿病协会的标准，将患者分为三组：无糖尿病受试者，HbA1c <5.7％；糖尿病前5.7％≤HbA1c <6.5％; 和2型糖尿病（T2DM），HbA1c≥6.5％。计算胰腺造影前的胰脏T1值和ECV，然后比较胰腺造影前的胰腺T1值，ECV和HbA1c值。本前瞻性研究已获得我们机构审查委员会的批准。所有患者均获得书面知情同意书。结果观察到HbA1c值与对比前胰腺T1值和ECV呈正相关（分别为r = 0.79，P <0.001和r = 0.60，P <0.001）。T2DM患者的对比前胰腺T1值和ECV显着高于无糖尿病对象和糖尿病前患者（P <0.001）。在两个定性值之间无显着差异（P = 0.14），但是，区分非糖尿病受试者和T2DM糖尿病前者的敏感性，特异性和受试者工作特征曲线下面积在ECV中优于（200％ ，93.5％和0.990）与对比前的胰腺T1值（84.6％，96.8％和0.906）相比。