New inherently radiopaque nanocomposites were prepared using iodine-containing poly(methyl methacrylate-co-acrylamide) and graphene oxide. For this purpose, P(MMA-co-AA) was synthesized via copolymerization of methyl methacrylate and acrylic acid, and modified with 4-iodophenyl isocyanate and 3,4,5-triiodophenyl isocyanate to form poly[(methyl methacrylate-co-(N-4-iodophenyl)acrylamide)] (1I-P(MMA-co-AA)) and poly[(methyl methacrylate-co-(N-3,4,5-triiodophenyl)acrylamide)] (3I-P(MMA-co-AA)), respectively. For comparative evaluation, the non-iodinated copolymer (PIC-P(MMA-co-AA)) was prepared via reaction of the P(MMA-co-AA) with phenyl isocyanate to investigate the effect of iodinated substituents on the morphology and thermal characteristics of the nanocomposites. All the nanocomposites were characterized by X-ray diffraction analysis, scanning electron microscopy, X-radiography and thermogravimetric analysis. The results proved that thermal properties of the nanocomposites improved by the introduction of different amounts of graphene oxide into the copolymers’ matrix. Radiopacity measurements showed the excellent radiopacity of iodinated nanocomposites and proved that 3I-GO-5 had radiopacity equivalent to that of an aluminium wedge with 2-mm thickness.Graphic abstract

中文翻译：

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使用生物相容性碘化聚（甲基丙烯酸甲酯-共丙烯酰胺）和氧化石墨烯合成和表征固有的不透射线纳米复合材料

使用含碘的聚（甲基丙烯酸甲酯-共-丙烯酰胺）和氧化石墨烯制备了新的固有不透射线纳米复合材料。为此，通过甲基丙烯酸甲酯和丙烯酸的共聚合成了 P(MMA-co-AA)，并用 4-碘苯基异氰酸酯和 3,4,5-三碘苯基异氰酸酯改性形成聚[(甲基丙烯酸甲酯-co-( N-4-碘苯基）丙烯酰胺）]（1I-P（MMA-co-AA））和聚[（甲基丙烯酸甲酯-co-（N-3,4,5-三碘苯基）丙烯酰胺）]（3I-P（MMA） -co-AA))，分别。为了进行比较评估，通过 P(MMA-co-AA) 与异氰酸苯酯的反应制备了非碘化共聚物 (PIC-P(MMA-co-AA))，以研究碘化取代基对形态和热的影响。纳米复合材料的特性。所有纳米复合材料均通过 X 射线衍射分析表征，扫描电子显微镜、X 射线照相术和热重分析。结果证明，通过将不同量的氧化石墨烯引入共聚物基质中，纳米复合材料的热性能得到改善。射线不透性测量表明碘化纳米复合材料具有出色的射线不透性，并证明 3I-GO-5 的射线不透性与 2 毫米厚的铝楔相当。图形摘要