Herein we report the synthesis of mesoporous nanostructures comprising copper (II) oxide {x[Cu(II)O]}\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\{x[\mathrm{Cu(II)O}]\}$$\end{document} immobilized on silica y[SiO2]\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${ y}[\mathrm{SiO}_{2}]$$\end{document} template for release of copper ions by precipitation via sol–gel technique. Three different specimens with increasing amount of Cu in the matrix with amount of Si being the same in all the samples, viz. ‘6Cu:5Si’, ‘4.5Cu:5Si’ and ‘3Cu:5Si’ where the numbers refer to the respective molar ratios of their respective domains, were prepared. Increase of crystallinity in the mesoporous material with increase in incorporation of copper domains consisting of CuO in SiO2\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {SiO}_{2}$$\end{document} matrix has been established. The average size of the CuO nanoparticle (NP) (domain) is 20–30 nm. The BET surface area has been found to be 276–390 m2g-1\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {m}^{2}\ \text {g}^{-1}$$\end{document} and Langmuir surface area has been found to be 422–605.9 m2g-1\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {m}^{2}\ \text {g}^{-1}$$\end{document} for the samples 5Si:3Cu–5Si:6Cu, respectively, having pore size of 4–6.5 nm. The cytotoxicity data show that the NPs are less toxic below concentration of 125μgml-1\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$125\ \upmu \text {g ml}^{-1}$$\end{document}. A steady increase in percentage of bacterial-‘Escherichia coli’, ‘Pseudomonas aeruginosa’ and ‘Bacillus subtilis’ cell death (indicated by decrease in optical density) due to increase in concentrations of NPs after incubation for 14 h, showing sensitivity even at very low concentrations (5–20 μ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\upmu $$\end{document}g), has been observed. A comparative antibacterial activity test among the three prepared specimens has been reported, which shows better antibacterial activity with the lowest copper concentration. Better antibacterial sensitivity when compared with equivalent amount of commercial CuO is established.

中文翻译：

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分散和固定在 y$$[\text {SiO}_{2}]$$[SiO2] 基质上的介孔 x[Cu(II)O] 纳米团簇：结构和对铜绿假单胞菌和枯草芽孢杆菌的有效控制杀生物活性

三个不同的试样，其基体中的 Cu 含量增加，所有样品中的 Si 含量相同，即。制备'6Cu:5Si'、'4.5Cu:5Si'和'3Cu:5Si'，其中数字指的是它们各自畴的各自摩尔比。随着在 SiO2\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{ 中加入由 CuO 组成的铜域的增加，介孔材料的结晶度增加amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {SiO}_{2}$$\end{document} 矩阵已经建立。CuO 纳米颗粒 (NP)（域）的平均尺寸为 20-30 nm。细胞毒性数据显示，NPs 在浓度低于 125μgml-1\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \ usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$125\ \upmu \text {g ml}^{-1}$$\end{document}。由于孵育 14 小时后 NPs 浓度增加，细菌 - '大肠杆菌'、'铜绿假单胞菌' 和 '枯草芽孢杆菌' 细胞死亡的百分比稳步增加（由光密度降低表示），即使在非常低的浓度（5–20 μ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\upmu $$\end{document}g)，已被观察到。已经报道了三种制备的样品之间的比较抗菌活性测试，表明在最低铜浓度下具有更好的抗菌活性。与等量的商业 CuO 相比，具有更好的抗菌敏感性。以最低的铜浓度显示出更好的抗菌活性。与等量的商业 CuO 相比，具有更好的抗菌敏感性。以最低的铜浓度显示出更好的抗菌活性。与等量的商业 CuO 相比，具有更好的抗菌敏感性。