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In Vitro Degradation and Cytocompatibility of As-Cast Mg-5Zn- x Sr Alloys
Journal of Materials Engineering and Performance ( IF 2.3 ) Pub Date : 2020-01-03 , DOI: 10.1007/s11665-019-04547-5
Gong Xiaole , Chen Jihua , Yan Hongge , Xia Weijun , Su Bin , Cheng Meixin , Yin Hui

The biodegradation behaviors and cytocompatibility of the as-cast Mg-5Zn-xSr alloys (≤ 1.0%) are carefully characterized by immersion testing, electrochemical measurement and cell proliferation and adhesion testing. The biodegradation rates increase in the order of Mg-5Zn-0.2Sr, Mg-5Zn-1Sr, Mg-5Zn-0.6Sr and Mg-5Zn in both 0.9%NaCl and Hank’s solution. The as-cast Mg-5Zn-0.2Sr alloy is the most corrosion resistant, which can be attributed to the finest grain size, the lower volume fraction of secondary phases and the higher stability of corrosion layer. Filiform corrosion along grain boundaries is dominant in the Mg-5Zn-0.2Sr alloy at the initial stage, and the cyclic polarization scans show that it has the highest pitting corrosion resistance. Grain size effect on corrosion is not as obvious as that of the secondary phases for the as-cast Mg-Zn-Sr alloys. The 0.2%Sr addition can reduce the biodegradation rate, promote the cell growth and improve the cell adhesion ability of the as-cast Mg-5Zn alloy, which is attractive for biomedical applications.

中文翻译:

铸态Mg-5Zn-x Sr合金的体外降解和细胞相容性

铸态Mg-5Zn- x的生物降解行为和细胞相容性通过浸没测试,电化学测量以及细胞增殖和粘附力测试对Sr合金(≤1.0%)进行了仔细表征。在0.9%NaCl和Hank's溶液中,其生物降解速率依次为Mg-5Zn-0.2Sr,Mg-5Zn-1Sr,Mg-5Zn-0.6Sr和Mg-5Zn。铸态的Mg-5Zn-0.2Sr合金具有最高的耐蚀性,这可以归因于最细的晶粒尺寸,较低的二次相体积分数和较高的腐蚀层稳定性。Mg-5Zn-0.2Sr合金在初始阶段沿晶界的丝状腐蚀占主导地位,循环极化扫描表明,它具有最高的耐点蚀性。晶粒尺寸对腐蚀的影响不如铸态Mg-Zn-Sr合金的第二相明显。添加0.2%Sr可降低生物降解率,
更新日期:2020-01-04
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