The lack in the literature of a simple, yet general and complete derivation of the widely used equation for non-compartmental calculation of steady-state volume of distribution is pointed out. It is demonstrated that the most frequently cited references contain an overly simplified explanation. The logical gap consists in doubly defining the same quantities without a proof the definitions are equivalent. Two alternative solutions are proposed: analytical derivation and hydrodynamic analogy. It is shown, that the problem can be analyzed in a purely macroscopic framework by utilizing the integral mean value of the function, without the need to resort to statistical distributions.

中文翻译：

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再谈非隔室稳态分配量。

指出在文献中缺乏简单，通用和完全推导的用于稳态分布体积的非室计算的广泛使用的方程。事实证明，最常引用的参考文献包含过于简化的解释。逻辑上的差距在于双重定义相同的数量，而没有证明定义是等效的。提出了两种替代解决方案：分析推导和流体动力学类比。结果表明，可以通过使用函数的积分平均值在纯宏观框架内分析问题，而无需求助于统计分布。