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Recent Developments in Highly Stereoselective Michael Addition Reactions Catalyzed by Metal Complexes
Synthesis ( IF 2.6 ) Pub Date : 2020-01-03 , DOI: 10.1055/s-0039-1690044 Alexander N. Reznikov 1 , Yuri N. Klimochkin
Synthesis ( IF 2.6 ) Pub Date : 2020-01-03 , DOI: 10.1055/s-0039-1690044 Alexander N. Reznikov 1 , Yuri N. Klimochkin
Affiliation
Achieving high enantioselectivity and diastereoselectivity simultaneously is a rather challenging task for asymmetric catalytic synthesis. Thanks to the rapid development of asymmetric transition-metal catalysis, significant progress has been made during recent years in achieving highly enantio- and diastereoselective conjugate addition reactions with a diverse combination of Michael donors and acceptors. This short review surveys the advances in transition-metal-catalyzed asymmetric diastereoselective Michael addition including diastereodivergent catalysis developed between 2015 and 2019. The review is divided into multiple parts according to the type of nucleophiles involved in the reaction.
中文翻译:
金属配合物催化的高立体选择性迈克尔加成反应的最新进展
对于不对称催化合成,同时实现高对映选择性和非对映选择性是一项颇具挑战性的任务。由于不对称过渡金属催化的迅速发展,近年来在通过迈克尔供体和受体的多种组合实现高度对映体和非对映选择性共轭加成反应方面取得了重大进展。这篇简短的综述调查了过渡金属催化的不对称非对映选择性Michael加成反应的进展,包括在2015年至2019年之间开发的非对映异构催化作用。该综述根据反应涉及的亲核试剂类型分为多个部分。
更新日期:2020-01-04
中文翻译:
金属配合物催化的高立体选择性迈克尔加成反应的最新进展
对于不对称催化合成,同时实现高对映选择性和非对映选择性是一项颇具挑战性的任务。由于不对称过渡金属催化的迅速发展,近年来在通过迈克尔供体和受体的多种组合实现高度对映体和非对映选择性共轭加成反应方面取得了重大进展。这篇简短的综述调查了过渡金属催化的不对称非对映选择性Michael加成反应的进展,包括在2015年至2019年之间开发的非对映异构催化作用。该综述根据反应涉及的亲核试剂类型分为多个部分。