当前位置: X-MOL 学术Antimicrob. Resist. Infect. Control › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Epidemiology of Carbapenem-resistant Enterobacteriaceae in Egyptian intensive care units using National Healthcare-associated Infections Surveillance Data, 2011-2017.
Antimicrobial Resistance & Infection Control ( IF 5.5 ) Pub Date : 2020-01-03 , DOI: 10.1186/s13756-019-0639-7
Sara Kotb 1 , Meghan Lyman 2 , Ghada Ismail 3 , Mohammad Abd El Fattah 4 , Samia A Girgis 5 , Ahmed Etman 4 , Soad Hafez 6 , Jehan El-Kholy 7 , Maysaa El Sayed Zaki 8 , Hebat-Allah G Rashed 9 , Ghada M Khalil 10 , Omar Sayyouh 1 , Maha Talaat 1
Affiliation  

Objective To describe the epidemiology of carbapenem-resistant Enterobacteriaceae (CRE) healthcare-associated infections (HAI) in Egyptian hospitals reporting to the national HAI surveillance system. Methods Design: Descriptive analysis of CRE HAIs and retrospective observational cohort study using national HAI surveillance data. Setting: Egyptian hospitals participating in the HAI surveillance system. The patient population included patients admitted to the intensive care unit (ICU) in participating hospitals. Enterobacteriaceae HAI cases were Klebsiella, Escherichia coli, and Enterobacter isolates from blood, urine, wound or respiratory specimen collected on or after day 3 of ICU admission. CRE HAI cases were those resistant to at least one carbapenem. For CRE HAI cases reported during 2011-2017, a hospital-level and patient-level analysis were conducted using only the first CRE isolate by pathogen and specimen type for each patient. For facility, microbiology, and clinical characteristics, frequencies and means were calculated among CRE HAI cases and compared with carbapenem-susceptible Enterobacteriaceae HAI cases through univariate and multivariate logistic regression using STATA 13. Results There were 1598 Enterobacteriaceae HAI cases, of which 871 (54.1%) were carbapenem resistant. The multivariate regression analysis demonstrated that carbapenem resistance was associated with specimen type, pathogen, location prior to admission, and length of ICU stay. Between 2011 and 2017, there was an increase in the proportion of Enterobacteriaceae HAI cases due to CRE (p-value = 0.003) and the incidence of CRE HAIs (p-value = 0.09). Conclusions This analysis demonstrated a high and increasing burden of CRE in Egyptian hospitals, highlighting the importance of enhancing infection prevention and control (IPC) programs and antimicrobial stewardship activities and guiding the implementation of targeted IPC measures to contain CRE in Egyptian ICU's .

中文翻译:

使用与国家医疗保健相关的感染监测数据,2011-2017,埃及重症监护病房中耐碳青霉烯类肠杆菌科的流行病学。

目的描述向国家HAI监测系统报告的埃及医院中对碳青霉烯耐药的肠杆菌科(CRE)医疗相关感染(HAI)的流行病学。方法设计:使用国家HAI监测数据对CRE HAI进行描述性分析和回顾性观察队列研究。地点:参与HAI监视系统的埃及医院。患者人群包括参与医院的重症监护室(ICU)入院的患者。在ICU入院第3天或之后收集的血液,尿液,伤口或呼吸道标本中分离出的肠杆菌科HAI病例为克雷伯菌,大肠杆菌和肠杆菌。CRE HAI病例是对至少一种碳青霉烯类药物有抗药性的病例。对于2011-2017年期间报告的CRE HAI案件,仅针对每个患者使用病原体和标本类型的第一个CRE分离株进行了医院和患者水平的分析。对于设施,微生物学和临床特征,计算了CRE HAI病例的频率和均值,并使用STATA 13通过单因素和多因素logistic回归与碳青霉烯易感性肠杆菌科HAI病例进行了比较。结果共有1598例HAI肠杆菌科病例,其中871(54.1 %)对碳青霉烯有抗药性。多元回归分析表明,碳青霉烯抗性与标本类型,病原体,入院前的位置以及ICU住院时间有关。在2011年至2017年之间,由于CRE(p值= 0.003)和CRE HAIs的发生率(p值= 0.09),肠杆菌科HAI病例的比例有所增加。
更新日期:2020-01-04
down
wechat
bug