Acyclovir is a synthetic deoxyguanosine analog that is used for the treatment of herpes simplex as well as varicella zoster virus infections. In this work, by incorporation of different deep eutectic solvents (DESs), ZnO nanoparticles, and multi-walled carbon nanotubes (MWCNTs) into the carbon paste matrix, and electropolymerization of arginine at the resulted electrode, new sensor was designed for improved sensing of acyclovir. The effect of influential factors on the electrode quality was investigated. As a result, the carbon paste electrode modified with 5% ZnO, 5% MWCNTs, 5% DES (choline chloride-urea) and applying10 cycles in polymeric condition exerted remarkable enhancement for acyclovir in physiological media (pH = 7). Two linear ranges have been obtained for the acyclovir concentration within the ranges of 0.01–0.33 and 0.33- $1.0~\mu \text{M}$ , with a detection limit of $0.007~\mu \text{M}$ . The excellent selectivity of sensor for the acyclovir determination was confirmed by discrimination of peaks for interferences (e.g. ascorbic acid, and guanine). Suitability of the fabricated sensor for acyclovir determination in pharmaceutical formulations and human fluid was confirmed with satisfactory results.

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在存在深共晶溶剂、纳米结构和聚合物的情况下提高阿昔洛韦传感性能

阿昔洛韦是一种合成的脱氧鸟苷类似物，用于治疗单纯疱疹和水痘带状疱疹病毒感染。在这项工作中，通过将不同的深共熔溶剂 (DESs)、ZnO 纳米粒子和多壁碳纳米管 (MWCNTs) 掺入碳糊基质中，并在所得电极上电聚合精氨酸，设计了新的传感器以改善对阿昔洛韦。研究了影响因素对电极质量的影响。结果，用 5% ZnO、5% MWCNTs、5% DES（氯化胆碱-尿素）修饰的碳糊电极在聚合条件下应用 10 个循环，对生理介质（pH = 7）中的阿昔洛韦表现出显着的增强。阿昔洛韦浓度在 0.01-0.33 和 0.33-范围内获得了两个线性范围 $1.0~\mu \text{M}$ , 检出限为 $0.007~\mu \text{M}$ . 通过对干扰峰（例如抗坏血酸和鸟嘌呤）的区分，证实了传感器对阿昔洛韦测定的出色选择性。制造的传感器适用于药物制剂和人体体液中的阿昔洛韦测定，结果令人满意。