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Divergent C–H activation synthesis of chalcones, quinolones and indoles†
Chemical Communications ( IF 6.164 ) Pub Date : 2020-01-03 , DOI: 10.1039/c9cc08926h
Yuesen Shi; Huimin Xing; Tianle Huang; Xuexin Liu; Jian Chen; Xiaoyu Guo; Guo-Bo Li; Yong Wu

We here report a condition-controlled divergent synthesis strategy of chalcones, quinolones and indoles, which was achieved via a C–H activation reaction of N-nitrosoanilines and cyclopropenones. Variations of Ag salts are observed to be crucial for divergently constructing the three distinct chemical scaffolds. A Rh(I)- and Rh(III)-cocatalyzed decarbonylation/C–H activation/[3+2] annulation cascade reaction was developed for the synthesis of indoles. These methodologies are characterized by mild reaction conditions, high functional group tolerance, and amenability to gram-scale synthesis, providing a reference for future derivation of new chemical scaffolds by C–H activation.
更新日期:2020-01-14

 

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