Background Prenatal alcohol exposure (PAE) can result in detrimental developmental complications. The objective of this study was to estimate the most recent PAE prevalence data for the state of West Virginia (WV) and associated factors. Method In all, 1830 newborn residual dried blood spots (DBS) in the WV Newborn Screening Repository were analyzed for phosphatidylethanol (PETH). Data were matched with Project WATCH data (94% match, N = 1729). Results The prevalence of late pregnancy PAE was 8.10% (95%CI: 6.81, 9.38) for all births, 7.61% (95%CI: 6.26, 8.97) for WV residents only, and ranged from 2.27 to 17.11% by region. The significant factors associated with PAE included smoking (OR: 2.03, 95% CI: 1.40, 2.94), preterm births (OR: 1.88; 95% CI: 1.23, 2.89), birth weight of ≤2000 g vs. >3000 g (OR: 2.62, 95%CI: 1.19, 5.79), no exclusive breastfeeding intention (OR: 1.45, 95% CI: 1.02, 2.04), and not exclusively breastfeeding before discharge (OR: 1.61; 95% CI: 1.09, 2.38). Conclusion The prevalence of PAE is higher than previously shown for the state. Accurate and timely estimates are vital to inform public health workers, policymakers, researchers, and clinicians to develop and promote effective prevention strategies to lower PAE prevalence and provide targeted interventions and treatment services for infants affected by PAE.

中文翻译：

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妊娠晚期饮酒的流行率

背景 产前酒精暴露 (PAE) 会导致有害的发育并发症。本研究的目的是估计西弗吉尼亚州 (WV) 和相关因素的最新 PAE 流行数据。方法 总共对西弗吉尼亚州新生儿筛查库中 1830 个新生儿残留干血斑 (DBS) 进行了磷脂酰乙醇 (PETH) 分析。数据与 Project WATCH 数据匹配（94% 匹配，N = 1729）。结果 晚孕PAE患病率为8.10% (95%CI: 6.81, 9.38)，仅WV居民为7.61% (95%CI: 6.26, 8.97)，各地区为2.27%～17.11%。与 PAE 相关的显着因素包括吸烟 (OR: 2.03, 95% CI: 1.40, 2.94)、早产 (OR: 1.88; 95% CI: 1.23, 2.89)、出生体重≤2000 g vs. >3000 g (或：2.62, 95% CI: 1.19, 5.79), 无纯母乳喂养意向（OR：1.45，95% CI：1.02，2.04），出院前未纯母乳喂养（OR：1.61；95% CI：1.09，2.38）。结论 该州的 PAE 患病率高于先前显示的。准确及时的估计对于告知公共卫生工作者、政策制定者、研究人员和临床医生制定和推广有效的预防策略以降低 PAE 患病率并为受 PAE 影响的婴儿提供有针对性的干预措施和治疗服务至关重要。