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Product Yield, Purity, and Effective Distribution Coefficient in Stripping Crystallization of R-2-Amino-1-phenylethanol from the Enantiomer Mixture
Crystal Growth & Design ( IF 3.8 ) Pub Date : 2020-01-21 , DOI: 10.1021/acs.cgd.9b01614
Lie-Ding Shiau

Stripping crystallization (SC) was applied for chiral purification of R-2-amino-1-phenylethanol (R-APE) from an enantiomer mixture. As SC is operated in a series of three-phase transformations by decreasing temperature and pressure, SC combines melt crystallization and vaporization to produce the R-APE crystalline product, and liquid phase and vapor phase of mixtures.

中文翻译:

R -2-氨基-1-苯基乙醇从对映异构体混合物中汽提结晶的产物收率,纯度和有效分配系数

汽提结晶(SC)用于从对映异构体混合物中手性纯化R- 2-氨基-1-苯基乙醇(R - APE)。由于通过降低温度和压力使SC在一系列三相转变中进行操作,因此SC将熔体结晶和汽化相结合以生成R -APE结晶产物以及混合物的液相和气相。
更新日期:2020-01-22
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