Introduction

The extirpation of skull base malignancies may be associated with significant morbidity and can profoundly impact health related quality of life (HRQOL). In this review, we sought to provide an overview of HRQOL and the factors that influence it for patients with skull base malignancies.

Materials and Methods

Narrative review.

Results

HRQOL tends to improve in the months to years following treatment and is profoundly impacted by both tumor location and treatment approach. Wherever possible, HRQOL should always be elicited from the patient directly. Several HRQOL instruments have been used in this population including generic, site-specific and disease specific measures.

Conclusion

Given that HRQOL is a multidimensional concept with several important facets, validated disease-specific instruments are generally preferred.

中文翻译：

---

前颅底和中央颅底恶性肿瘤患者的生活质量考虑。

介绍

颅底恶性肿瘤的切除可能与显着的发病率有关，并且会严重影响健康相关的生活质量 (HRQOL)。在这篇综述中，我们试图对颅底恶性肿瘤患者的 HRQOL 及其影响因素进行概述。

材料和方法

叙事评论。

结果

HRQOL 在治疗后的数月至数年内趋于改善，并且受到肿瘤位置和治疗方法的深刻影响。在可能的情况下，HRQOL 应始终直接从患者身上得出。已在该人群中使用了多种 HRQOL 工具，包括通用的、特定于地点的和特定于疾病的措施。

结论

鉴于 HRQOL 是一个具有多个重要方面的多维概念，通常首选经过验证的针对特定疾病的工具。