当前位置: X-MOL 学术J. Infect. Dis. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Population-Level Human Secretor Status Is Associated With Genogroup 2 Type 4 Norovirus Predominance.
The Journal of Infectious Diseases ( IF 6.4 ) Pub Date : 2020-05-11 , DOI: 10.1093/infdis/jiz693
Cory J Arrouzet 1 , Karen Ellis 1 , Anita Kambhampati 2, 3 , Yingxi Chen 4 , Molly Steele 5 , Ben Lopman 1, 2, 5
Affiliation  

BACKGROUND Noroviruses are a leading cause of acute gastroenteritis. Genogroup 2 type 4 (GII.4) has been the dominant norovirus genotype worldwide since its emergence in the mid-1990s. Individuals with a functional fucosyltransferase-2 gene, known as secretors, have increased susceptibility to GII.4 noroviruses. We hypothesized that this individual-level trait may drive GII.4 norovirus predominance at the human population level. METHODS We conducted a systematic review for studies reporting norovirus outbreak or sporadic case genotypes and merged this with data on proportions of human secretor status in various countries from a separate systematic review. We used inverse variance-weighted linear regression to estimate magnitude of the population secretor-GII.4 proportion association. RESULTS Two hundred nineteen genotype and 112 secretor studies with data from 38 countries were included in the analysis. Study-level GII.4 proportion among all noroviruses ranged from 0% to 100%. Country secretor proportion ranged from 43.8% to 93.9%. We observed a 0.69% (95% confidence interval, 0.19-1.18) increase in GII.4 proportion for each percentage increase in human secretor proportion, controlling for Human Development Index. CONCLUSIONS Norovirus evolution and diversity may be driven by local population human host genetics. Our results may have vaccine development implications including whether specific antigenic formulations would be required for different populations.

中文翻译:

人群水平的人类分泌物状态与Genogroup 2 4型诺如病毒的优势相关。

背景诺如病毒是急性胃肠炎的主要原因。自1990年代中期以来,基因组2 4型(GII.4)一直是全球主要的诺如病毒基因型。具有功能性岩藻糖基转移酶2基因(称为分泌物)的个体对GII.4诺如病毒的敏感性增加。我们假设这种个人水平的性状可能在人口水平上推动GII.4诺如病毒的流行。方法我们对报告诺如病毒暴发或偶发病例基因型的研究进行了系统的综述,并将其与来自不同国家的人类分泌物状况比例数据分开进行了系统综述。我们使用逆方差加权线性回归来估计总体分泌物-GII.4比例关联的大小。结果该分析包括219个基因型和112个分泌物研究,这些数据来自38个国家。在所有诺如病毒中,研究水平的GII.4比例为0%至100%。国家秘书的比例从43.8%到93.9%不等。我们观察到,随着人类分泌物比例的每增加一个百分比,GII.4比例就会增加0.69%(95%置信区间,0.19-1.18),从而控制了人类发展指数。结论诺如病毒的进化和多样性可能是由当地人群的人类宿主遗传学驱动的。我们的结果可能会对疫苗开发产生影响,包括不同人群是否需要特定的抗原制剂。国家秘书的比例从43.8%到93.9%不等。我们观察到,随着人类分泌物比例的每增加一个百分比,GII.4比例就会增加0.69%(95%置信区间,0.19-1.18),从而控制了人类发展指数。结论诺如病毒的进化和多样性可能是由当地人群的人类宿主遗传学驱动的。我们的结果可能会对疫苗开发产生影响,包括不同人群是否需要特定的抗原制剂。国家秘书的比例从43.8%到93.9%不等。我们观察到,随着人类分泌物比例的每增加一个百分比,GII.4比例就会增加0.69%(95%置信区间,0.19-1.18),从而控制了人类发展指数。结论诺如病毒的进化和多样性可能是由当地人群的人类宿主遗传学驱动的。我们的结果可能会对疫苗开发产生影响,包括不同人群是否需要特定的抗原制剂。
更新日期:2020-01-04
down
wechat
bug