Doctor Tan's paper insightfully describes how epigenomic investigations of twins can help clarifying the mediation between environmental pressures, the genome, and behaviour. Here, I will expand on two emerging implications and their connections to the twin method. The first proposition deals with the transgenerational inheritance of epigenetic marks. The second examines the relationship between DNA methylation (DNAmeth) and mutation rate (MR), and their evolutionary implications.

中文翻译：

---

表观基因组景观及其与变异，适应性和进化的关系。

Tan博士的论文深刻地描述了双胞胎的表观基因组学研究如何帮助阐明环境压力，基因组和行为之间的中介作用。在这里，我将介绍两个新出现的含义以及它们与twin方法的关系。第一个命题涉及表观遗传标记的跨代遗传。第二部分研究了DNA甲基化（DNAmeth）与突变率（MR）之间的关系，以及它们的进化意义。