Zeolitic imidazole framework (ZIF) is an emerging class of metal organic frameworks exhibiting unique features such as crystalline nature with tunable pore size, large surface area and biocompatible nature. Exceptional thermal and chemical stabilities of ZIF-L make it a suitable candidate for biomedical applications. The present study has focused on the single step fabrication of catechin encapsulated ZIF-L and evaluation of its antibiofilm efficiency, larvicidal activity and dye degradation ability. The as- prepared CA@ZIF-L nanocomposite was characterized by spectroscopic and microscopic techniques. The results revealed that the CA@ZIF-L showed significant toxicity against mosquito larvae in a dose dependent manner with the IC50 63.43±1.25 μg/mL. CA@ZIF-L showed dose dependent reduction of biofilm formation in both ATCC and clinical MRSA strains. In addition, CA@ZIF-L exhibited excellent photocatalytic activity with around 92% degradation of methylene blue under direct sunlight. Overall, the present work highlights the possibility of employing the multifunctional CA@ZIF-L nanocomposite as a suitable material for biomedical and photocatalytic applications.

中文翻译：

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一锅法制备多功能儿茶素@ ZIF-L纳米复合材料：评估抗生物膜，杀幼虫和光催化活性。

沸石咪唑骨架（ZIF）是一类新兴的金属有机骨架，具有独特的功能，例如具有可调节孔径的结晶性，大表面积和生物相容性。ZIF-L具有出色的热稳定性和化学稳定性，使其非常适合生物医学应用。本研究集中于儿茶素包封的ZIF-L的一步制备及其抗生物膜效率，杀幼虫活性和染料降解能力的评估。通过光谱和显微镜技术表征了所制备的CA @ ZIF-L纳米复合材料。结果表明，CA @ ZIF-L对蚊虫幼虫具有显着的剂量依赖性，IC50为63.43±1.25μg/ mL。CA @ ZIF-L在ATCC和临床MRSA菌株中均显示出剂量依赖性的生物膜形成减少。此外，CA @ ZIF-L表现出优异的光催化活性，在阳光直射下亚甲基蓝的降解率约为92％。总的来说，本工作突出了将多功能CA @ ZIF-L纳米复合材料用作生物医学和光催化应用的合适材料的可能性。