The three known gasotransmitters, nitric oxide, carbon monoxide, and hydrogen sulfide are involved in key processes throughout pregnancy. Gasotransmitters are known to impact on smooth muscle tone, regulation of immune responses, and oxidative state of cells and their component molecules. Failure of the systems that tightly regulate gasotransmitter production and downstream effects are thought to contribute to common maternal diseases such as preeclampsia and preterm birth. Normal pregnancy-related changes in uterine blood flow depend heavily on gasotransmitter signaling. In preeclampsia, endothelial dysfunction is a major contributor to aberrant gasotransmitter signaling, resulting in hypertension after 20 weeks gestation. Maintenance of pregnancy to term also requires gasotransmitter-mediated uterine quiescence. As the appropriate signals for parturition occur, regulation of gasotransmitter signaling must work in concert with those endocrine signals in order for appropriate labor and delivery timing. Like preeclampsia, preterm birth may have origins in abnormal gasotransmitter signaling. We review the evidence for the involvement of gasotransmitters in preeclampsia and preterm birth, as well as mechanistic and molecular signaling targets.

中文翻译：

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产妇疾病和气体递质。

在整个怀孕期间，三种已知的气体递质，一氧化氮，一氧化碳和硫化氢都参与了关键过程。已知气体递质会影响平滑肌的张力，免疫反应的调节以及细胞及其组成分子的氧化状态。人们认为，严格调节汽油递质产生和下游影响的系统的故障会导致常见的孕产妇疾病，例如先兆子痫和早产。正常妊娠相关的子宫血流变化在很大程度上取决于气体递质信号。在子痫前期中，内皮功能障碍是异常的气体递质信号传导的主要诱因，在妊娠20周后导致高血压。维持妊娠至足月还需要由气体传导介质介导的子宫静止。当出现适当的分娩信号时，必须对气体传输信号的调节与这些内分泌信号协同工作，以确保适当的分娩和分娩时机。像子痫前期一样，早产可能起源于异常的气体递质信号传导。我们审查了先兆子痫和早产中涉及气体递质的证据，以及机制和分子信号转导靶点。