Corni Fructus, also known as the fruit of Cornus officinalis Sieb. et Zucc., has long been used as a traditional Chinese medicine and is widely consumed as a nutritional food in the form of function drink and wine. Recently, Corni Fructus has attracted considerable interest because of its anti-diabetic effects. A systematic phytochemical investigation of Corni Fructus was performed to find anti-diabetic components, which led to the isolation of 10 unreported iridoid glycosides, cornusdiglycosides A-J (1-8, 9a/9b and 10a/10b). Their chemical structures were determined through spectroscopic analysis (ultraviolet [UV], infrared [IR], high-resolution electrospray ionisation mass spectroscopy [HRESIMS], one-dimensional [1D] and two-dimensional [2D] nuclear magnetic resonance [NMR]). Such morroniside-type diglycosides were first reported from natural sources, and all isolates were evaluated for α-glucosidase inhibitory activity. The results showed that all compounds (1-10) exhibited α-glucosidase (from Saccharomyces cerevisiae) inhibitory activities with IC50 values ranging from 78.9 ± 4.09 to 162.2 ± 9.17 μM, whereas acarbose, the positive control, displayed α-glucosidase inhibitory activity with IC50 value of 118.9 ± 7.89 μM.

中文翻译：

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来自山茱萸的具有 α-葡萄糖苷酶抑制活性的未描述的莫诺苷类二环苷酸二糖苷

Corni Fructus，也被称为山茱萸的果实。et Zucc. 长期以来被用作中药，并以功能饮料和酒的形式作为营养食品被广泛食用。最近，山茱萸因其抗糖尿病作用引起了人们的极大兴趣。对山茱萸进行了系统的植物化学研究，以寻找抗糖尿病成分，从而分离出 10 种未报告的环烯醚萜苷、山茱萸二糖苷 AJ（1-8、9a/9b 和 10a/10b）。它们的化学结构是通过光谱分析（紫外线 [UV]、红外线 [IR]、高分辨率电喷雾电离质谱 [HRESIMS]、一维 [1D] 和二维 [2D] 核磁共振 [NMR]）确定的. 这种莫诺苷型二糖苷首先从天然来源报道，并评估了所有分离物的 α-葡萄糖苷酶抑制活性。结果表明，所有化合物（1-10）均表现出α-葡萄糖苷酶（来自酿酒酵母）抑制活性，IC50值为78.9±4.09至162.2±9.17μM，而阳性对照阿卡波糖显示出α-葡萄糖苷酶抑制活性IC50 值为 118.9 ± 7.89 μM。