Our understanding of intratumoral heterogeneity in cancer continues to evolve, with current models incorporating single-cell signatures to explore cell–cell interactions and differentiation state. The transition between stem and differentiation states in nonneoplastic cells requires metabolic plasticity, and this plasticity is increasingly recognized to play a central role in cancer biology. The insights from hematopoietic and neural stem cell differentiation pathways were used to identify cancer stem cells in leukemia and gliomas. Similarly, defining metabolic heterogeneity and fuel-switching signals in nonneoplastic stem cells may also give important insights into the corresponding molecular mechanisms controlling metabolic plasticity in cancer. These advances are important, because metabolic adaptation to anticancer therapeutics is rooted in this inherent metabolic plasticity and is a therapeutic challenge to be overcome.

中文翻译：

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代谢可塑性在血液和脑干细胞病理生理中的作用

我们对癌症中肿瘤内异质性的理解不断发展，目前的模型结合了单细胞特征来探索细胞间相互作用和分化状态。非肿瘤细胞中茎和分化状态之间的过渡需要代谢可塑性，这种可塑性在癌症生物学中起着核心作用。来自造血干细胞和神经干细胞分化途径的见解被用于鉴定白血病和神经胶质瘤中的癌症干细胞。同样，在非肿瘤干细胞中定义代谢异质性和燃料转换信号也可能为控制癌症中代谢可塑性的相应分子机制提供重要见解。这些进步很重要，