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Relationship between ocular involvement and clinical manifestations, laboratory findings, and coronary artery dilatation in Kawasaki disease
Eye ( IF 3.9 ) Pub Date : 2020-01-03 , DOI: 10.1038/s41433-019-0762-y
Reza Shiari 1 , Mohsen Jari 1 , Saeed Karimi 2, 3 , Omid Salehpour 4 , Khosro Rahmani 1 , Mehrnoosh Hassas Yeganeh 1 , Vadood Javadi Parvaneh 1 , Shabnam Hajian 1 , Leyla Ghasemi 1 , Sare Safi 5
Affiliation  

Objectives To assess the incidence of ocular manifestations of Kawasaki disease (KD) in children and to evaluate the relationship between ocular manifestations and the other clinical manifestations, laboratory findings, and echocardiographic findings. Methods Complete ophthalmologic examination and echocardiography were performed in 36 patients with KD during the acute phase before starting the treatment. Clinical manifestations and laboratory data including white blood cell (WBC) count, neutrophil-to-lymphocyte ratio, platelet count, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were obtained from all the patients. All the clinical and laboratory findings were compared between the group with ocular involvement and the one without ocular involvement. Results The incidence of bilateral non-exudative conjunctivitis was 63.9%. It was significantly higher in patients with skin rashes ( P < 0.05). The incidence of uveitis was 36.1%, which consisted primarily of grade 1+ or 2+ acute anterior uveitis. Neutrophil count and CRP levels were significantly higher in the uveitis group than in the group without uveitis ( P < 0.05). Coronary artery dilatation showed significant correlation with uveitis ( P < 0.05). Uveitis did not show a significant correlation with other clinical manifestations, ESR, ALT level, AST level, and platelet count ( P > 0.05). Conclusion In children with Kawasaki disease, uveitis is associated with coronary artery dilatation, higher neutrophil count, and higher CRP level.

中文翻译:

川崎病眼部受累与临床表现、实验室检查结果和冠状动脉扩张的关系

目的 评估儿童川崎病(KD)眼部表现的发生率,并评估眼部表现与其他临床表现、实验室检查结果和超声心动图检查结果之间的关系。方法对36例KD急性期患者在开始治疗前进行全面眼科检查和超声心动图检查。临床表现和实验室数据,包括白细胞 (WBC) 计数、中性粒细胞与淋巴细胞比率、血小板计数、红细胞沉降率 (ESR)、C 反应蛋白 (CRP) 以及丙氨酸氨基转移酶 (ALT) 和天冬氨酸氨基转移酶水平(AST) 来自所有患者。比较眼部受累组和非眼部受累组的所有临床和实验室检查结果。结果双侧非渗出性结膜炎发生率为63.9%。皮疹患者显着升高( P < 0.05)。葡萄膜炎的发生率为 36.1%,主要由 1+ 或 2+ 级急性前葡萄膜炎组成。葡萄膜炎组中性粒细胞计数和CRP水平显着高于无葡萄膜炎组( P < 0.05)。冠状动脉扩张与葡萄膜炎显着相关( P < 0.05)。葡萄膜炎与其他临床表现、血沉、ALT水平、AST水平和血小板计数均无显着相关性( P > 0.05)。结论川崎病患儿葡萄膜炎与冠状动脉扩张、中性粒细胞计数升高和CRP水平升高有关。皮疹患者显着升高( P < 0.05)。葡萄膜炎的发生率为 36.1%,主要由 1+ 或 2+ 级急性前葡萄膜炎组成。葡萄膜炎组中性粒细胞计数和CRP水平显着高于无葡萄膜炎组( P < 0.05)。冠状动脉扩张与葡萄膜炎显着相关( P < 0.05)。葡萄膜炎与其他临床表现、血沉、ALT水平、AST水平和血小板计数均无显着相关性( P > 0.05)。结论川崎病患儿葡萄膜炎与冠状动脉扩张、中性粒细胞计数升高和CRP水平升高有关。皮疹患者显着升高( P < 0.05)。葡萄膜炎的发生率为 36.1%,主要由 1+ 或 2+ 级急性前葡萄膜炎组成。葡萄膜炎组中性粒细胞计数和CRP水平显着高于无葡萄膜炎组( P < 0.05)。冠状动脉扩张与葡萄膜炎显着相关( P < 0.05)。葡萄膜炎与其他临床表现、血沉、ALT水平、AST水平和血小板计数均无显着相关性( P > 0.05)。结论川崎病患儿葡萄膜炎与冠状动脉扩张、中性粒细胞计数升高和CRP水平升高有关。葡萄膜炎组中性粒细胞计数和CRP水平显着高于无葡萄膜炎组( P < 0.05)。冠状动脉扩张与葡萄膜炎显着相关( P < 0.05)。葡萄膜炎与其他临床表现、血沉、ALT水平、AST水平和血小板计数均无显着相关性( P > 0.05)。结论川崎病患儿葡萄膜炎与冠状动脉扩张、中性粒细胞计数升高和CRP水平升高有关。葡萄膜炎组中性粒细胞计数和CRP水平显着高于无葡萄膜炎组( P < 0.05)。冠状动脉扩张与葡萄膜炎显着相关( P < 0.05)。葡萄膜炎与其他临床表现、血沉、ALT水平、AST水平和血小板计数均无显着相关性( P > 0.05)。结论川崎病患儿葡萄膜炎与冠状动脉扩张、中性粒细胞计数升高和CRP水平升高有关。
更新日期:2020-01-03
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