Background Prognostic factors for TB-associated uveitis (TBU) remain mostly unknown, due to the challenges in interpretation of patient data. We present consensus list of prognostic factors for resolution of inflammation in TBU, by experts across the Asia-Pacific region. Methods We applied a modified Delphi technique to generate consensus on prognostic factors influencing the resolution of inflammation in TB-associated: anterior uveitis (AU), retinal vasculitis (RV), and multifocal serpiginoid choroiditis (MSC). The initial questionnaire was developed through a face-to-face meeting. Sixteen uveitis experts from eleven Asia-Pacific countries were included. A single investigator circulated the questionnaire electronically and received the responses. Participants scored each item on 4-point Likert scale, in three successive rounds. After each round, a number of items were reduced based on response, and summary of responses was provided to participants. At the end of Round 3, items were considered significant if they: (1) achieved a median ≥2, and interquartile range ≤1, and (2) ≥75% of the respondents agreed on whether the item was a positive or negative prognostic factor. Results Forty-two putative questionnaire items were considered. At the end of Rounds 3, 4, 9, and 8 items in AU, RV, and MSC, respectively, met significance criteria. These included duration of disease, previous corticosteroid/immunosuppressive therapy, co-existent HIV, disease-specific imaging features, multidrug resistant TB, and duration of anti-TB therapy. Conclusions Consensus were achieved on multiple ocular and systemic factors that influence resolution of inflammation in TBU. These will form the groundwork for validation in prospective clinical trials.

中文翻译：

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亚太地区结核病相关葡萄膜炎的预后因素：修正的德尔福调查结果

背景 由于在解释患者数据方面存在挑战，TB 相关性葡萄膜炎 (TBU) 的预后因素大多仍然未知。我们提供了亚太地区专家对 TBU 炎症消退预后因素的共识列表。方法 我们应用改良的 Delphi 技术就影响 TB 相关炎症消退的预后因素达成共识：前葡萄膜炎 (AU)、视网膜血管炎 (RV) 和多灶性蛇皮细胞样脉络膜炎 (MSC)。最初的问卷是通过面对面的会议制定的。包括来自 11 个亚太国家的 16 位葡萄膜炎专家。一名调查员以电子方式分发问卷并收到答复。参与者在连续三轮中以 4 点李克特量表对每个项目进行评分。每轮过后，根据答复减少了一些项目，并向参与者提供了答复摘要。在第 3 轮结束时，如果满足以下条件，项目被认为是显着的：(1) 达到中位数≥2，四分位距≤1，和 (2) ≥75% 的受访者同意该项目是积极还是消极的预后因素。结果 考虑了 42 个假定的问卷项目。在第 3、4、9 和 8 轮结束时，AU、RV 和 MSC 中的项目分别符合显着性标准。这些包括疾病持续时间、以前的皮质类固醇/免疫抑制治疗、共存的 HIV、疾病特异性影像学特征、耐多药结核病和抗结核治疗的持续时间。结论 就影响 TBU 炎症消退的多个眼部和全身因素达成共识。