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Mechanisms of Hantavirus Transmission in Oligoryzomys longicaudatus.
EcoHealth ( IF 2.5 ) Pub Date : 2019-12-02 , DOI: 10.1007/s10393-019-01454-y
Ernesto Juan 1 , Silvana Levis 2 , Noemí Pini 2 , Jaime Polop 3 , Andrea R Steinmann 3 , María Cecilia Provensal 3
Affiliation  

The cricetid rodent Oligoryzomys longicaudatus is the species host of Andes virus (ANDV) which causes hantavirus pulmonary syndrome in southern Argentina and Chile. Population density, behavioral interactions, and spacing patterns are factors that affect viral transmission among wild rodents. We predict that the highest prevalence of hantavirus antibody positive would be found among wounded, reproductive males and that, at high population densities, wounded, reproductive males would be dispersers rather than resident individuals. The study was conducted seasonally from October (spring) 2011 to October (spring) 2013 in a shrubland habitat of Cholila, Argentina. During each trapping session, we classified captured O. longicaudatus as resident or disperser individuals, estimated population density, and recorded wounds as an indicator of aggression among individuals. We obtained blood samples from each individual for serological testing. We used generalized linear models to test the statistical significance of association between antibody prevalence, and sex, resident/dispersal status, wounds and trapping session. The highest proportion of seropositive O. longicaudatus individuals was among wounded reproductive males during periods of the greatest population density, and the characteristics of seroconverted individuals support that transmission is horizontal through male intrasexual competition. A positive association between dispersing individuals and hantavirus antibody was detected at high population density. Our study design allowed us to obtain data on a large number of individuals that are seroconverted, enabling a better understanding of the ecology and epidemiology of the ANDV host system.

中文翻译:

汉坦病毒在长叶寡卵中的传播机制。

啮齿类啮齿动物Oligoryzomys longicaudatus是安第斯病毒(ANDV)的宿主,该病毒在阿根廷南部和智利引起汉坦病毒性肺综合征。种群密度,行为相互作用和间隔模式是影响野生啮齿动物之间病毒传播的因素。我们预测,在受伤的生殖力男性中汉坦病毒抗体阳性率最高,并且在高人口密度下,受伤的生殖力男性将是分散者,而不是居民。该研究是从2011年10月(春季)到2013年10月(春季)在阿根廷乔利拉的灌木丛生境中季节性进行的。在每个诱捕会话中,我们对捕获的长脊O鱼进行了分类作为居民或散居者的个人,估计人口密度,并记录伤口作为个人之间侵略性的指标。我们从每个人那里获取血液样本进行血清学检测。我们使用广义线性模型来检验抗体患病率与性别,居民/分散状态,伤口和诱捕时间之间的关联的统计显着性。血清阳性的长曲霉比例最高在人口密度最大的时期内,这些人是生殖生殖男性中的一员,血清转化个体的特征支持通过男性内部性竞争进行水平传播。在高人口密度下检测到分散的个体与汉坦病毒抗体之间呈正相关。我们的研究设计使我们能够获得大量经过血清转化的个体的数据,从而可以更好地了解ANDV宿主系统的生态学和流行病学。
更新日期:2019-12-02
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