The aim of this study was to analyze dental comorbidities in untreated primary hyperparathyroidism (pHPT). Patients with pHPT subjected to parathyroidectomy (PTX) at Karolinska University Hospital, Stockholm, during 2011–2016 (n = 982) were selected from the Scandinavian Quality Register of Thyroid, Parathyroid and Adrenal surgery and compared to a general population cohort (n = 2944), matched for age and gender. Dental data was obtained from the Swedish Dental Health Registry for the 3 years prior to PTX. The incidence rate ratios (IRRs) of tooth loss by extraction, periodontal interventions, and dental visit rate were analyzed by Poisson regression models. In order to analyze the impact of disease severity, the PHPT cohort was sub-grouped based on preoperative serum levels of ionized calcium (S-Ca²⁺). The total number of tooth extractions, periodontal interventions, and number of visits were similar in the cohorts. PHPT patients belonging to the quartile with the highest S-Ca²⁺ (≥ 1.51 mmol/L) had increased risk for tooth extraction (IRR 1.85; 95% CI 1.39–2.46). Female gender independently amplified the risk (IRR 1.341, P < 0.027). This study indicates an association between pHPT and oral disorders reflected by increased tooth loss by extraction related to high S-Ca². Increased awareness of dental comorbidity in primary hyperparathyroidism may benefit a large group of patients with a common disease through earlier detection and prevention.

本研究的目的是分析未经治疗的原发性甲状旁腺功能亢进症（pHPT）中的牙齿合并症。PHPT患者在2011-2016（卡罗林斯卡大学医院，斯德哥尔摩，进行甲状旁腺切除（PTX）ñ  = 982）是从甲状腺，甲状旁腺及肾上腺手术的斯堪的纳维亚质量注册选择相比一般人群队列（ñ = 2944），匹配了年龄和性别。牙科数据是从瑞典牙科健康登记处获得PTX之前3年的数据。通过泊松回归模型分析了拔牙，牙周干预和牙齿访视率造成的牙齿脱落发生率（IRR）。为了分析疾病严重程度的影响，根据术前血清离子钙（S-Ca ²⁺）水平对PHPT队列进行了分组。队列中拔牙，牙周干预和就诊的总数相似。属于S-Ca ²⁺最高（≥1.51 mmol / L）的四分位数的PHPT患者拔牙的风险增加（IRR 1.85； 95％CI 1.39–2.46）。女性性别独立地增加了风险（IRR 1.341，P <0.027）。这项研究表明，pHPT与口腔疾病之间的相关性反映出与高S-Ca ²相关的拔牙增加了牙齿的脱落。通过早期发现和预防，增加对原发性甲状旁腺功能亢进症牙齿合并症的认识可能会使一大批患有普通疾病的患者受益。