The recent literature has revolutionized our view on the vital importance of endoplasmic reticulum (ER)-associated degradation (ERAD) in health and disease. Suppressor/enhancer of Lin-12-like (Sel1L)-HMG-coA reductase degradation protein 1 (Hrd1)-mediated ERAD has emerged as a crucial determinant of normal physiology and as a sentinel against disease pathogenesis in the body, in a largely substrate- and cell type-specific manner. In this Review, we highlight three features of ERAD, constitutive versus inducible ERAD, quality versus quantity control of ERAD and ERAD-mediated regulation of nuclear gene transcription, through which ERAD exerts a profound impact on a number of physiological processes.

中文翻译：

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ER相关的健康和疾病退化-从底物到生物。

最近的文献彻底改变了我们关于内质网（ER）相关降解（ERAD）在健康和疾病中的至关重要性的观点。Lin-12样（Sel1L）-HMG-coA还原酶降解蛋白1（Hrd1）介导的ERAD的抑制剂/增强剂已成为正常生理的关键决定因素，并且在很大程度上是作为抵抗体内疾病发病机制的前哨兵。 -和特定于细胞类型的方式。在这篇综述中，我们重点介绍了ERAD的三个特征：ERAD的组成性与诱导型，ERAD的质量与数量控制以及ERAD介导的核基因转录调控，ERAD通过它们对许多生理过程产生了深远的影响。