Introduction: Previous studies performed neuropsychological tests in non-demented patients, especially those with mild cognitive impairment (MCI), to predict dementia. Few recent studies reported that subjective cognitive decline (SCD) itself predicts dementia conversion. We evaluated certain characteristics and neuropsychological tests to predict cognitive deterioration in non-demented individuals.Methods: This study included 106 participants with subjective cognitive complaints (SCCs) classified as non-demented (90 MCI and 16 SCD). Data were collected at baseline and follow-up, wherein participants completed a comprehensive neuropsychological assessment to assess their cognitive and daily functions.Results: During the follow-up of all participants, 52 converted to dementia, while 54 did not. There were significant differences in age and education years, as well as language, memory, frontal lobe function, and Barthel's Activities of Daily Living Index between the groups. Correlation analysis showed a significant correlation between the deterioration of the Clinical Dementia Rating scores and baseline language, memory, and frontal lobe function scores.Conclusion(s): SCDs consistently worrying about their SCCs and those identified with SCD by their caregivers were prone to cognitive function deterioration over time. Changes in language, memory, and frontal lobe function in neurocognitive tests were significantly different between the dementia converters and non dementia converters group. Particularly, SCD and MCI individuals with significantly poor initial executive function and memory abilities should be closely monitored for future cognitive decline.

中文翻译：

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非痴呆型个体认知退化的神经心理学预测因子。

简介：先前的研究对未痴呆的患者（尤其是轻度认知障碍（MCI）的患者）进行了神经心理学测试，以预测痴呆。很少有研究报道主观认知能力下降（SCD）本身可以预测痴呆症的转化。我们评估了某些特征和神经心理学测试，以预测非痴呆者的认知能力下降。方法：本研究包括106名受试者，其主观认知投诉（SCC）被归类为非痴呆（90 MCI和16 SCD）。在基线和随访时收集数据，其中参与者完成了全面的神经心理学评估，以评估他们的认知和日常功能。结果：在所有参与者的随访中，有52例转变为痴呆，而54例则没有。两组之间在年龄和受教育年限，语言，记忆，额叶功能和Barthel的日常生活活动指数方面存在显着差异。相关性分析显示临床痴呆评估评分的恶化与基线语言，记忆力和额叶功能评分之间存在显着相关性。结论：SCD持续担心其SCC以及由其看护者鉴定为SCD的人容易出现认知障碍功能随着时间的推移而恶化。神经认知测试中语言，记忆和额叶功能的变化在痴呆症转化者和非痴呆症转化者组之间有显着差异。尤其，