Serpina3n is a secretory serine protease inhibitor belonging to clade "a" exhibiting unique structural and physiological characteristics, playing significant roles ranging from complement cascade, apoptosis, wound healing to Alzheimer by inhibiting a wide range of proteases. Recently studies have reported its significant roles during various pathologies. Although its full range of potential applications are yet to reveal, its reported implications particularly in CNS insults are making it potential therapeutical approach. Here we aim to draw together the literature shedding light on the potential therapeutical applications of Serpina3n/SERPINA3 in various diseases and a brief comparison between murine Serpina3n and its human ortholog SERPINA3 (α1-antichymotrypsin) accounting their biological roles and significance.

中文翻译：

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Serpina3n：潜在的药物和挑战，小型审查。

Serpina3n 是一种分泌型丝氨酸蛋白酶抑制剂，属于进化枝“a”，具有独特的结构和生理特征，通过抑制多种蛋白酶发挥着从补体级联、细胞凋亡、伤口愈合到阿尔茨海默病的重要作用。最近的研究报告了其在各种病理过程中的重要作用。尽管其全部潜在应用尚未揭示，但其报道的影响尤其是在 CNS 损伤方面的影响使其成为潜在的治疗方法。在这里，我们旨在汇集有关 Serpina3n/SERPINA3 在各种疾病中的潜在治疗应用的文献，并简要比较鼠类 Serpina3n 与其人类直系同源物 SERPINA3（α1-抗胰凝乳蛋白酶）之间的生物学作用和意义。