Human leukocyte antigen (HLA) mismatches between donors and recipients may lead to alloreactivity after solid organ transplantation. Over the last few decades, our knowledge of the complexity of the HLA system has dramatically increased, as numerous new HLA alleles have been identified. As a result, the likelihood of alloreactive responses towards HLA mismatches after solid organ transplantation cannot easily be assessed. Algorithms are promising solutions to estimate the risk for alloreactivity after solid organ transplantation. In this review, we show that the recently developed PIRCHE-II (Predicted Indirectly ReCognizable HLA Epitopes) algorithm can be used to minimize alloreactivity towards HLA mismatches. Together with the use of other algorithms and simulation approaches, the PIRCHE-II algorithm aims for a better estimated alloreactive risk for individual patients and eventually an improved graft survival after solid organ transplantation.

中文翻译：

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PIRCHE-II：一种在实体器官移植中预测间接可识别的HLA表位的算法。

供体和受体之间的人类白细胞抗原（HLA）错配可能导致实体器官移植后的同种异体反应。在过去的几十年中，由于已经发现了许多新的HLA等位基因，我们对HLA系统复杂性的了解大大增加了。结果，固体器官移植后对HLA错配的同种异体反应的可能性难以评估。算法是有前景的解决方案，用于估计实体器官移植后的同种异体反应风险。在这篇综述中，我们表明，最近开发的PIRCHE-II（预测的间接可识别HLA表位）算法可用于最小化对HLA不匹配的同种异体反应。结合使用其他算法和模拟方法，