When choosing the best action from several alternatives, we compare each value that depends on the balance between benefit and cost. Previous studies have shown that animals and humans with low brain serotonin (5-HT) level tend to choose smaller immediate reward. We used a decision-making schedule task to investigate whether 5-HT1A receptor is responsible for the decisions related to reward. In this task, the monkeys chose either of two different alternatives that were comprised of 1-4 drops of liquid reward (benefit) and 1-4 repeats of a color discrimination trial (workload cost), then executed the chosen schedule. By the administration of 5-HT1A antagonist, WAY100635, the choice tendency did not change, however, the sensitivity to the amount of reward in the schedule part was diminished. The 5-HT1A could have a role in maintaining reward value to keep track with the promised reward rather than modulating workload discounting of reward value.

中文翻译：

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5-HT1A受体拮抗剂对基于奖励的决策的影响。

从多种选择中选择最佳行动时，我们将比较每个价值，这些价值取决于收益和成本之间的平衡。先前的研究表明，脑5-羟色胺（5-HT）水平低的动物和人类倾向于选择较小的即时奖励。我们使用了决策计划任务来调查5-HT1A受体是否负责与奖励有关的决策。在这项任务中，猴子选择了两种不同的替代方法之一，这些替代方法包括1-4滴液体奖励（好处）和1-4次颜色辨别试验的重复（工作量成本），然后执行选择的时间表。通过施用5-HT1A拮抗剂WAY100635，选择趋势没有改变，但是，对计划部分的报酬金额的敏感性降低了。