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Pathology and natural history of organ fibrosis.
Current Opinion in Pharmacology ( IF 4 ) Pub Date : 2019-11-02 , DOI: 10.1016/j.coph.2019.09.009
Joaquim Majo 1 , Barbara Mara Klinkhammer 2 , Peter Boor 2 , Dina Tiniakos 3
Affiliation  

Histopathological assessment of fibrosis focusing on morphological patterns provides important information for the management of patients with chronic diseases of the kidney, liver and the lung. This review summarizes key histopathological features of pulmonary, renal and hepatic fibrosis and discusses advances in the understanding of the pathogenesis of pulmonary fibrosis and pathogenetic insights with translational implications for renal fibrosis. The review also tackles new staging approaches based on liver fibrosis dynamics and evaluation of fibrosis regression, digital pathology and second harmonic generation microscopy methods for hepatic fibrosis assessment and critical appraisal of non-invasive tests for liver and renal fibrosis evaluation.

中文翻译:

器官纤维化的病理学和自然史。

着眼于形态学模式的纤维化的组织病理学评估为管理患有肾脏,肝脏和肺部慢性疾病的患者提供了重要信息。这篇综述总结了肺,肾和肝纤维化的关键组织病理学特征,并讨论了对肺纤维化发病机理的理解和对肾脏纤维化具有转化意义的致病性见解的进展。该综述还探讨了基于肝纤维化动力学和肝纤维化消退评估,数字病理学和二次谐波显微镜技术的新分期方法,以评估肝纤维化以及肝和肾纤维化评估的非侵入性检查的严格评估。
更新日期:2019-10-28
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