The microbial production of natural products has been traditionally accomplished in a single organism engineered to accommodate target biosynthetic pathways. Often times, such approaches result in large metabolic burdens as key cofactors, precursor metabolites and energy are channeled to pathways of structurally complex chemicals. Recently, modular co-culture engineering has emerged as a new approach to efficiently conduct heterologous biosynthesis and greatly enhance the production of natural products. This review highlights recent advances that leverage Escherichia coli-based modular co-culture engineering for making natural products. Potential future perspectives for studies in this promising field are addressed as well.

中文翻译：

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用于天然产物合成的模块化共培养工程的最新进展。

传统上，天然产物的微生物生产是在经过改造以适应目标生物合成途径的单个生物中完成的。通常，由于关键辅因子，前体代谢物和能量被引导到结构复杂的化学物质的途径中，因此这些方法会导致很大的代谢负担。最近，模块化共培养工程技术已经成为一种有效进行异源生物合成并大大提高天然产物产量的新方法。这篇综述重点介绍了利用基于大肠杆菌的模块化共培养工程制造天然产物的最新进展。在这个有前途的领域研究的潜在未来前景也得到了解决。