Nearly all microbes rely on other species in their environment to provide nutrients they are unable to produce. Nutritional interactions include not only the exchange of carbon and nitrogen compounds, but also amino acids and cofactors. Interactions involving cross-feeding of cobamides, the vitamin B12 family of cofactors, have been developed as a model for nutritional interactions across species and environments. In addition to experimental studies, new developments in culture-independent methodologies such as genomics and modeling now enable the prediction of nutritional interactions in a broad range of organisms including those that cannot be cultured in the laboratory. New insights into the mechanisms and evolution of microbial nutritional interactions are beginning to emerge by combining experimental, genomic, and modeling approaches.

中文翻译：

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发现和预测微生物营养相互作用的多方面方法。

几乎所有微生物都依靠其环境中的其他物种提供无法生产的营养。营养相互作用不仅包括碳和氮化合物的交换，还包括氨基酸和辅因子的交换。已经开发了涉及交叉喂食cobamide（辅因子的维生素B12家族）的相互作用，作为跨物种和环境进行营养相互作用的模型。除了实验研究之外，与文化无关的方法学（例如基因组学和建模）的新发展现在可以预测广泛的生物体中的营养相互作用，包括那些不能在实验室中培养的生物体。通过结合实验，基因组和建模方法，对微生物营养相互作用的机制和进化的新见解开始出现。