Abstract

Three-finger snake neurotoxins are selective antagonists of some nicotinic acetylcholine receptor subtypes and are widely used to study these receptors. The peptide neurotoxin azemiopsin, recently isolated from the venom of Azemipos feae, is a selective blocker of muscle-type nicotinic acetylcholine receptor. In order to reduce their toxicity and increase resistance under physiological conditions, we have encapsulated these toxins into nanomaterials. The study of nanomaterials after interaction with neurotoxins by the methods of transmission electron microscopy and dynamic light scattering revealed an increase in the size of nanoparticles, which indicates the inclusion of neurotoxins in nanomaterials.

中文翻译：

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神经毒素，烟碱乙酰胆碱受体的阻滞剂，在基于硫酸多糖的纳米材料中的封装。

摘要

三指蛇神经毒素是某些烟碱样乙酰胆碱受体亚型的选择性拮抗剂，被广泛用于研究这些受体。最近从Azemipos feae的毒液中分离出的肽类神经毒素阿奇米星是一种肌肉型烟碱乙酰胆碱受体的选择性阻滞剂。为了降低它们的毒性并在生理条件下增加抗药性，我们将这些毒素封装在纳米材料中。通过透射电子显微镜和动态光散射方法与神经毒素相互作用后对纳米材料的研究表明纳米颗粒的尺寸增加，这表明纳米材料中包含神经毒素。