Diarrhea is a gastrointestinal symptom associated with systemic anaphylaxis and could be induced by increased colonic motility. We determined colonic motility and expulsion by measuring the intracolonic pressure (ICP) and expelled fluid weight in anesthetized rats during anaphylactic hypotension. Substantial systemic hypotension occurred in every sensitized rat after antigen injection. One min after antigen injection, ICP began to increase and remained elevated for 5 min, which was revealed to represent tonic contraction by the video-recording procedure, and was accompanied by increased colonic fluid expulsion. Parasympathectomy composed of subdiaphragmatic vagotomy combined with pelvic nerve transection reduced the duration of the tonic contraction, but not expelled colonic fluid. Furthermore, denervation of afferent parasympathetic nerves produced essentially the same effect as parasympathectomy. Sympathectomy did not significantly change any parameters. In conclusion, the colonic motility during anaphylactic hypotension is characterized by 5-min lasting tonic contraction which is associated with increased colonic fluid expulsion and is involved by parasympathetic nerves, especially their afferents, but not sympathetic nerves, in anesthetized rats.

中文翻译：

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在麻醉性大鼠过敏性低血压期间，结肠出现强直收缩。

腹泻是一种与全身过敏反应有关的胃肠道症状，可以由结肠运动性增强引起。我们通过测量过敏性低血压期间麻醉大鼠的结肠内压（ICP）和排出的液体重量来确定结肠的运动和排出。抗原注射后，每只致敏大鼠均发生全身性低血压。抗原注射后一分钟，ICP开始升高并持续升高5分钟，这通过视频记录程序表明其表现为强直性收缩，并伴有结肠液排出增加。由dia下迷走神经切断术结合盆腔神经横断组成的副交感神经切除术缩短了补剂收缩的持续时间，但没有排出结肠液。此外，副交感神经的去神经化产生的效果与副交感神经切除术基本相同。交感神经切除术没有明显改变任何参数。总之，过敏性低血压期间结肠运动的特征是持续5分钟的强直收缩，这与增加结肠液排出有关，并且在麻醉的大鼠中由副交感神经特别是其传入神经参与，但不与交感神经有关。