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Blockade of 5-HT2A receptors inhibits emotional hyperthermia in mice.
The Journal of Physiological Sciences ( IF 2.3 ) Pub Date : 2019-08-20 , DOI: 10.1007/s12576-019-00703-7
Vanshika Sinh 1 , Youichirou Ootsuka 1
Affiliation  

This study determined whether blockade of 5-hydroxytryptamine 2A (5-HT2A) receptors attenuated hyperthermia and tachycardia responses to psychological stress in mice. For this purpose, male mice (C57BL/6N) were pre-instrumented with a telemetric probe to measure core body temperature and heart rate prior to experimentation. Vehicle or 5-HT2A antagonist, eplivanserin hemifumarate (SR-46349B) ((1Z,2E)-1-(2-fluorophenyl)-3-(4-hydroxyphenyl)-2-propen-1-one O-[2-(dimethylamino) ethyl] oxime hemifumarate) (0.5, 1.0, 5.0 mg/kg), was injected intraperitoneally. To elicit psychological stress, an intruder male mouse confined to a small cage was introduced into the resident mouse's cage 30 min after administration of the injection. The application of this psychological stress increased body temperature by ~ 1.0 °C and heart rate by ~ 150 bpm in the vehicle group. In contrast, SR-46349B was shown to reduce this psychological stress-induced increase in body temperature in a dose-dependent manner (P < 0.05). However, the SR-46349B treatment groups had no influence on the intruder-elicited increase in heart rate. This study, therefore, suggests that 5-HT2A receptors play a significant role in mediating hyperthermia, but not tachycardia, during intruder-elicited psychological stress.

中文翻译:

5-HT2A受体的阻滞抑制小鼠的情绪高热。

这项研究确定了5-羟色胺2A(5-HT2A)受体的阻滞是否减弱了小鼠对心理压力的热疗和心动过速反应。为此,在进行实验之前,先用遥测探针对雄性小鼠(C57BL / 6N)进行预测量,以测量其核心体温和心率。媒介物或5-HT2A拮抗剂,半富马酸eplivanserin(SR-46349B)(((1Z,2E)-1-(2-氟苯基)-3-(4-羟基苯基)-2-丙烯-1-酮O- [2-(腹膜内注射(二甲基氨基)乙基]肟半富马酸酯)(0.5、1.0、5.0mg / kg)。为了引起心理压力,在注射注射后30分钟,将局限在小笼子中的入侵雄性小鼠引入常驻小鼠的笼子中。这种心理压力的应用会使体温升高约1。车辆组中的0°C和心率〜150 bpm。相反,显示SR-46349B以剂量依赖的方式减少这种心理压力引起的体温升高(P <0.05)。但是,SR-46349B治疗组对入侵者引起的心率增加没有影响。因此,这项研究表明5-HT2A受体在入侵者引起的心理压力期间在介导热疗中起重要作用,而在心动过速中不起作用。
更新日期:2019-11-01
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