To adequately connect zebrafish medical models to human biology, it is essential that gene nomenclature reflects gene orthology. Analysis of gene phylogenies and conserved syntenies shows that the zebrafish gene currently called wnt11 (ENSDARG00000004256, ZFIN ID: ZDB-GENE-990603-12) is not the ortholog of the human gene called WNT11 (ENSG00000085741); instead, the gene currently called wnt11r (ENSDARG00000014796, ZFIN ID: ZDB-GENE-980526-249) is the zebrafish ortholog of human WNT11. Genomic analysis of Wnt11-family genes suggests a model for the birth of Wnt11-family gene ohnologs in genome duplication events, provides a mechanism for the death of a Wnt11-family ohnolog in mammals after they diverged from birds, and suggests revised nomenclature to better connect teleost disease models to human biology.

中文翻译：

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脊椎动物Wnt11-家族基因的进化起源和命名。

为了将斑马鱼医学模型与人类生物学充分联系起来，至关重要的是基因命名法可以反映出基因的正交性。基因系统发育和保守性同源性分析表明，目前称为wnt11（ENSDARG00000004256，ZFIN ID：ZDB-GENE-990603-12）的斑马鱼基因与人类WNT11（ENSG00000085741）的直系同源。相反，当前称为wnt11r的基因（ENSDARG00000014796，ZFIN ID：ZDB-GENE-980526-249）是人WNT11的斑马鱼直系同源物。Wnt11家族基因的基因组分析表明，在基因组复制事件中Wnt11家族基因同源物的诞生模型，为哺乳动物与鸟类分离后的Wnt11家族同源物死亡提供了一种机制，并建议对命名法进行修改以更好地将硬骨动物疾病模型与人类生物学联系起来。