Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), the main effectors of the Hippo pathway, are emerging as important players in cancer biology and therapy response. The intracellular localization of YAP/TAZ is a key determinant in the regulation of their activity and their roles in signal transduction. This is particularly relevant for cancer: Aberrant nuclear localization of YAP and TAZ has been observed in numerous human cancers and may therefore represent an attractive target for cancer therapy. In this review, we describe the mechanisms that regulate the nucleo-cytoplasmic shuttling of YAP/TAZ and their implications for cancer, and discuss how the new insights about this process may pave the way for novel therapeutic strategies.

中文翻译：

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YAP / TAZ核质穿梭的新见解：新的癌症治疗机会？

Yes相关蛋白（YAP）和具有PDZ结合基序（TAZ）的转录共激活因子（河马途径的主要效应物）正在成为癌症生物学和治疗反应中的重要角色。YAP / TAZ的细胞内定位是调节其活性及其在信号转导中作用的关键决定因素。这与癌症特别相关：在许多人类癌症中都观察到YAP和TAZ的异常核定位，因此可能代表了癌症治疗的诱人靶标。在这篇综述中，我们描述了调节YAP / TAZ核仁穿梭的机制及其对癌症的影响，并讨论了有关这一过程的新见识如何为新型治疗策略铺平道路。