The role of mast cells (MCs) in type 2 diabetes (T2D) is not thoroughly studied as much as in T1D. Therefore in the current study we investigated correlation between these cells and various parameters of islets of Langerhans (IOL) in rats which were equally divided (n = 40) into; control and diabetic groups. We detected a significantly increased (p < 0.05) MC count (MCC) in the diabetic IOL compared to the control, together with a noticeable intra-islet seeding of these cells which displayed a tryptase positive immunostaining. A significant positive correlation (p < 0.05) between MCC and the % of glucagon cells per islet was detected in DM, unlike mass of the islets, mass of β-cells, and % of β-cells per islet which were negatively correlated with MCC. Similarly, there was a negative correlation between MCC with β-cell proliferation and neogenesis frequency in DM. This highlights the potential association between the increased MC number and the diminished islet`s mass as well as regeneration which may fasten the progression of T2D.

中文翻译：

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肥大细胞数量增加与2型糖尿病大鼠的β细胞量减少和再生有关。

肥大细胞（MCs）在2型糖尿病（T2D）中的作用没有像在T1D中那样被彻底研究。因此，在当前的研究中，我们研究了这些细胞与朗格汉斯（IOL）胰岛各参数之间的相关性，这些参数被平均分为（n = 40）。对照组和糖尿病人群。与对照组相比，我们在糖尿病IOL中检测到MC计数（MCC）显着增加（p <0.05），并且这些细胞的胰岛内播种明显表现出类胰蛋白酶阳性的免疫染色。在DM中，MCC与胰岛中胰高血糖素细胞的百分比之间存在显着的正相关（p <0.05），这与胰岛的质量，β细胞的质量以及每个胰岛的β细胞的百分比与MCC呈负相关性不同。同样，DM中MCC与β细胞增殖和新生频率呈负相关。这突显出增加的MC数量和减少的胰岛质量以及再生之间的潜在关联，这可能会加快T2D的进程。